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| MITE Accession | Status | Enzyme Name | Reaction Tailoring Term | Enzyme Description | Taxonomy Organism | Taxonomy Family | Reaction Description |
|---|---|---|---|---|---|---|---|
| MITE0000001 | AviG2 | Methylation | O-methyltransferase | Streptomyces viridochromogenes Tue57 | Streptomycetaceae | AviG2 is responsible for methylation of the hydroxyl group at position 6... | |
| MITE0000002 | AviG4 | Methylation | O-methyltransferase | Streptomyces viridochromogenes Tue57 | Streptomycetaceae | O-methyltransferase and is responsible for the methylation of the phenol... | |
| MITE0000003 | AviG6 | Methylation | O-methyltransferase | Streptomyces viridochromogenes Tue57 | Streptomycetaceae | AviG6 for methylation of the hydroxyl group at position 2 of the D-manno... | |
| MITE0000004 | AviG5 | Methylation | O-methyltransferase | Streptomyces viridochromogenes Tue57 | Streptomycetaceae | methylation of the hydroxyl group at position 4 of the D-fucose moiety | |
| MITE0000005 | CalO3 | Halogenation | Flavin-dependent halogenase | Micromonospora echinospora | Micromonosporaceae | Iodination of orsellenic acid derivate, assumed to be bound to coenzyme ... | |
| MITE0000006 | CalO6 | Methylation | O-methyltransferase | Micromonospora echinospora | Micromonosporaceae | O-methylation of orsellenic acid, assumed to be bound to coenzyme A cofactor | |
| MITE0000007 | CalO1 | Methylation | O-methyltransferase | Micromonospora echinospora | Micromonosporaceae | O-methylation of iodinated orsellenic acid derivate, assumed to be bound... | |
| MITE0000008 | CalO2 | Hydroxylation | Cytochrome P450 | Micromonospora echinospora | Micromonosporaceae | Hydroxylation of iodinated orsellenic acid derivate, assumed to be bound... | |
| MITE0000009 | MeiD | Methylation | O-methyltransferase | Streptomyces nanchangensis | Streptomycetaceae | N/A | |
| MITE0000010 | MeiE | Heterocyclization|Hydroxylation | Cytochrome P450 | Streptomyces nanchangensis | Streptomycetaceae | N/A | |
| MITE0000011 | MpaG | Methylation | O-methyltransferase | Penicillium brevicompactum | Eurotiomycetes | Catalyzes the O-methylation of demethylmycophenolic acid into mycophenolic acid | |
| MITE0000012 | GrhO5 | Monooxygenation | Flavoprotein monooxygenase | Streptomyces sp. JP95 | Streptomycetaceae | N/A | |
| MITE0000013 | GrhO6 | Monooxygenation | Flavoprotein monooxygenase | Streptomyces sp. JP95 | Streptomycetaceae | N/A | |
| MITE0000014 | MtmMI | Methylation | O-methyltransferase | Streptomyces argillaceus | Streptomycetaceae | 4-DPMC is the first stable intermediate of the mithramycin biosynthesis.... | |
| MITE0000015 | MtmMII | Methylation | C-methyltransferase | Streptomyces argillaceus | Streptomycetaceae | C-methylation in the mithramycin biosynthetic pathway. | |
| MITE0000016 | MtmOIV | Decarboxylation|Oxidation | Oxygenase | Streptomyces argillaceus | Streptomycetaceae | N/A | |
| MITE0000017 | MtmW | Reduction | Ketoreductase | Streptomyces argillaceus | Streptomycetaceae | N/A | |
| MITE0000018 | MtmGIV | Glycosylation | Glycosyltransferase | Streptomyces argillaceus | Streptomycetaceae | N/A | |
| MITE0000019 | MtmGIII | Glycosylation | Glycosyltransferase | Streptomyces argillaceus | Streptomycetaceae | N/A | |
| MITE0000020 | MtmGII | Glycosylation | Glycosyltransferase | Streptomyces argillaceus | Streptomycetaceae | N/A | |
| MITE0000021 | SsfM2 | Methylation | O-methyltransferase | Streptomyces sp. SF2575 | Streptomycetaceae | O-methylation of the tetracyclin intermediate | |
| MITE0000022 | SsfM4 | Methylation | C-methyltransferase | Streptomyces sp. SF2575 | Streptomycetaceae | SsfM4 catalyzes C6-methylation | |
| MITE0000023 | SsfM1 | Methylation | O-methyltransferase | Streptomyces sp. SF2575 | Streptomycetaceae | O-methylation of tetrycycline intermediate. | |
| MITE0000024 | XanH | Halogenation | FAD Halogenase | Streptomyces flavogriseus | Streptomycetaceae | Chlorinates the xantholipin intermediate. | |
| MITE0000027 | OxyC | Cyclization | Cytochrome P450 | Amycolatopsis balhimycina | Pseudonocardiaceae | Installs a biaryl ether bond on the balhiycin precursor. The reaction mi... | |
| MITE0000028 | BhaA | Halogenation | Halogenase | Amycolatopsis balhimycina | Pseudonocardiaceae | The halogenase chlorinates the second bht residue of the balhimycin prec... | |
| MITE0000029 | KtzQ | Halogenation | Flavin-dependent halogenase | Kutzneria sp. (strain 744) | Pseudonocardiaceae | KtzQ is a regiospecific halogenase that catalyzes the chlorination of L-... | |
| MITE0000030 | KtzR | Halogenation | Flavin-dependent halogenase | Kutzneria sp. (strain 744) | Pseudonocardiaceae | KtzR is a regiospecific halogenase that catalyzes chlorination at the 6-... | |
| MITE0000031 | SacF | Methylation | C-methyltransferase | Pseudomonas fluorescens | Pseudomonadaceae | N/A | |
| MITE0000032 | SfmM2 | Methylation | C-methyltransferase | Streptomyces lavendulae | Streptomycetaceae | Mediates the methylation of tyrosine into 3-methyl-L-tyrosine (3-Me-Tyr)... | |
| MITE0000033 | GtfB | Glycosylation | Glycosyltransferase | Actinoplanes teichomyceticus | Micromonosporaceae | Adds N-acetylglucosamine or N-acylglucosamine to Hpg4 of the teicoplanin... | |
| MITE0000034 | GtfA | Glycosylation | Glycosyltransferase | Actinoplanes teichomyceticus | Micromonosporaceae | Glycosyltransferase adds N-acetylglucosamine to Bht6 of the teicoplanin... | |
| MITE0000035 | Tcp24/Orf2*/tAtf | Acylation|Hydrolysis | Acyltransferase | Actinoplanes teichomyceticus | Micromonosporaceae | Deacetylates N-acetylglucosaminyl residue on Hpg4 of the teicoplanin precursor. | |
| MITE0000037 | GtfE | Glycosylation | Glycosyltransferase | Amycolatopsis orientalis | Pseudonocardiaceae | Transfers glucose onto hpg4 in the vancomycin and teicoplanin aglycone. | |
| MITE0000038 | OxyA | Cyclization|Oxidation | Cytochrome P450 | Amycolatopsis orientalis | Pseudonocardiaceae | Introduces the second biaryl-ether crosslink between bht2 and hpg4 in th... | |
| MITE0000039 | Vmt | Methylation | N-methyltransferase | Amycolatopsis orientalis | Pseudonocardiaceae | Methylates the N-terminus of the vancomycin backbone. Substrate specific... | |
| MITE0000040 | VhaA | Halogenation | Flavin-dependent halogenase | Amycolatopsis orientalis | Pseudonocardiaceae | Chlorinates bht 2 and bht 6 of vancomycin. The bond to the PCP domain of... | |
| MITE0000041 | OxyB | Cyclization|Oxidation | Cytochrome P450 | Amycolatopsis orientalis | Pseudonocardiaceae | Introduces the first biaryl-ether crosslink between hpg4 and bht6 in the... | |
| MITE0000042 | GtfD | Glycosylation | Glycosyltransferase | Amycolatopsis orientalis | Pseudonocardiaceae | Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone. | |
| MITE0000043 | SgvP | Heterocyclization | Cytochrome P450 | Streptomyces griseoviridis | Streptomycetaceae | N/A | |
| MITE0000044 | BotCYP | Decarboxylation|Oxidation | Cytochrome P450 | Streptomyces sp. BC16019 | Streptomycetaceae | P450-catalyzed oxidative decarboxylation of terminal thiazoline of bottr... | |
| MITE0000045 | BotOMT | Methylation | O-methyltransferase | Streptomyces sp. BC16019 | Streptomycetaceae | O-methylating SAM-dependent carboxyl methyltransferase from Streptomyces... | |
| MITE0000046 | BotRMT2 | Methylation | C-methyltransferase | Streptomyces sp. BC16019 | Streptomycetaceae | Bottromycin-precursor acting rSAM methyltransferase from Streptomyces sp... | |
| MITE0000047 | BotRMT3 | Methylation | C-methyltransferase | Streptomyces sp. BC16019 | Streptomycetaceae | Bottromycin-precursor acting rSAM methyltransferase from Streptomyces sp... | |
| MITE0000048 | BotP | Hydrolysis | Peptidase | Streptomyces sp. BC16019 | Streptomycetaceae | Cleavage of N-terminal Met from a NH2-Met-Gly-Pro-Xn chain, exposing a N... | |
| MITE0000049 | BotRMT1 | Methylation | C-methyltransferase | Streptomyces sp. BC16019 | Streptomycetaceae | Catalysis of radical C-methylation of Phe6 of bottromycin-precursor afte... | |
| MITE0000050 | BotAH | Hydrolysis | Aminohydrolase | Streptomyces sp. BC16019 | Streptomycetaceae | Cleaves modified bottromycin precursor peptide between thiazole8 and Met9. | |
| MITE0000051 | BotH | Epimerization | Epimerase | Streptomyces sp. BC16019 | Streptomycetaceae | epimerization of L-Asp7 to D-Asp7 of modified bottromycin precursor peptide | |
| MITE0000052 | BotC | Heterocyclization | YcaO protein | Streptomyces sp. BC16019 | Streptomycetaceae | thiazole heterocyclisation of Cys8 of bottromycin-precursor | |
| MITE0000053 | BotCD | Cyclization | YcaO protein | Streptomyces sp. BC16019 | Streptomycetaceae | macroamidine macrocyclization of Gly1 and Val4 of bottromycin-precursor | |
| MITE0000054 | MibH | Halogenation | Flavin-dependent halogenase | Microbispora corallina | Streptosporangiaceae | Flavin-dependent tryptophan-5-halogenase catalyzed halogenation reaction... | |
| MITE0000055 | McjC | Macrolactam formation | Macrolactam synthetase | Escherichia coli | Enterobacteriaceae | Lassopeptide macrolactam formation after N-terminal cleavage: NH2-G-G-X-... | |
| MITE0000056 | McjB | Hydrolysis | Peptidase | Escherichia coli | Enterobacteriaceae | ATP-dependent N-terminal cleavage of leader peptide, resulting in immatu... | |
| MITE0000057 | PntE | Oxidation | Baeyer-Villiger monooxygenase | Streptomyces arenae | Streptomycetaceae | Catalyzes the flavin-dependent Baeyer-Villiger oxidation in the biosynth... | |
| MITE0000058 | PntD | Dehydration|Oxidation | Non-heme iron-dependent dehydrogenase/oxygenase | Streptomyces arenae | Streptomycetaceae | N/A | |
| MITE0000059 | PntM | Other | Cytochrome P450 | Streptomyces arenae | Streptomycetaceae | Catalyzes oxidative rearrangement of final step in pentalenolactone pathway | |
| MITE0000060 | PntI | Oxidation | Cytochrome P450 | Streptomyces arenae | Streptomycetaceae | Carboxylation of intermediate in pentalenolactone biosynthetic pathway | |
| MITE0000061 | CotB3 | Hydroxylation | Cytochrome P450 | Streptomyces melanosporofaciens | Streptomycetaceae | Hydroxylation of the substrate pentacycle | |
| MITE0000062 | CotB4 | Hydroxylation | Cytochrome P450 | Streptomyces melanosporofaciens | Streptomycetaceae | N/A | |
| MITE0000063 | PtlD | Dehydration|Oxidation | Non-heme iron-dependent dehydrogenase/oxygenase | Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) | Streptomycetaceae | N/A | |
| MITE0000064 | PtlI | Oxidation | Cytochrome P450 | Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) | Streptomycetaceae | Catalyzes oxidation of pentalen-13-al in the neopentalenolactone pathway | |
| MITE0000065 | PtlE | Oxidation | Baeyer-Villiger monooxygenase | Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) | Streptomycetaceae | Catalyzes the flavin-dependent Baeyer-Villiger oxidation in the biosynth... | |
| MITE0000066 | RebP | Oxidation | Cytochrome P450 | Lentzea aerocolonigenes | Pseudonocardiaceae | Oxidative cyclization of chromopyrrolic acid. | |
| MITE0000067 | RebD | Oxidation | Dichlorochromopyrrolate synthase | Lentzea aerocolonigenes | Pseudonocardiaceae | N/A | |
| MITE0000068 | RebO | Oxidation | Flavin-dependent L-tryptophan oxidase | Lentzea aerocolonigenes | Pseudonocardiaceae | N/A | |
| MITE0000069 | RebH | Halogenation | Tryptophan halogenase | Lentzea aerocolonigenes | Pseudonocardiaceae | Chlorinates the rebeccamycin intermediate. | |
| MITE0000070 | RebC | Oxidation | Putative FAD-monooxygenase | Lentzea aerocolonigenes | Pseudonocardiaceae | FAD-dependent enzyme RebC catalyse the oxidation of two carboxylic acids... | |
| MITE0000071 | Bmp2 | Halogenation | Flavin-dependent halogenase | Pseudoalteromonas phenolica O-BC30 | Pseudoalteromonadaceae | N/A | |
| MITE0000072 | TdaE | Dioxygenation | Flavoprotein dioxygenase | Phaeobacter inhibens DSM 17395 | Roseobacteraceae | TdaE relies on its substrate as electron donor (rather than NAD(P)H) for... | |
| MITE0000073 | ClmAH | Hydrolysis | Amidohydrolase | Streptomyces sp. CS40 | Streptomycetaceae | removal of the leucine residue | |
| MITE0000074 | ClmM1 | Methylation | S-methyltransferase | Streptomyces sp. CS40 | Streptomycetaceae | N/A | |
| MITE0000075 | ClmM2 | Methylation | O-methyltransferase | Streptomyces sp. CS40 | Streptomycetaceae | O-methylation of collismycin D | |
| MITE0000076 | JamD | Halogenation | Flavin-dependent halogenase | Lyngbya majuscula | Oscillatoriales | Flavin-dependent bromination of terminal alkyne | |
| MITE0000077 | MdpB1 | Methylation | C-methyltransferase | Actinomadura madurae | Thermomonosporaceae | C-methylation of methylsalicylic acid bound to coenzyme A. Auxiliary enz... | |
| MITE0000080 | PokMT1 | Methylation | C-methyltransferase | Streptomyces diastatochromogenes | Streptomycetaceae | C-methylation of methylsalicylic acid bound to coenzyme A. Auxiliary enz... | |
| MITE0000081 | AgqB | Hydroxylation | Alkylresorcinol monooxygenase | Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431) | Micromonosporaceae | Hydroxylation of alkylresorcinol substrate. | |
| MITE0000082 | AgqC | Methylation | O-methyltransferase | Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431) | Micromonosporaceae | N/A | |
| MITE0000083 | AgqD | Prenylation | UbiA-like prenyltransferase | Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431) | Micromonosporaceae | N/A | |
| MITE0000084 | NapB2 | Oxidation | Monooxygenase | Streptomyces aculeolatus | Streptomycetaceae | Oxidation of 1,3,6,8-tetrahydroxynaphthalene (THN) to flaviolin. | |
| MITE0000085 | NapB5 | Methylation | C-methyltransferase | Streptomyces aculeolatus | Streptomycetaceae | N/A | |
| MITE0000086 | NapH1 | Halogenation|Heterocyclization | Vanadium-dependent chloroperoxidase | Streptomyces aculeolatus | Streptomycetaceae | N/A | |
| MITE0000087 | RslO4 | Monooxygenation | Monooxygenase | Streptomyces bottropensis | Streptomycetaceae | RslO4 catalyzes the monooxygenation of an intermediate in the rishirilid... | |
| MITE0000088 | TlmF | Oxidation | Cytochrome P450 | Salinispora pacifica DSM 45543 = CNS-863 | Micromonosporaceae | N/A | |
| MITE0000090 | TPS21 | Cyclization | Terpene cyclase | Solanum lycopersicum | Spermatophyta | Cyclization of nerylneryl diphosphate to form lycosantalene | |
| MITE0000091 | CYP71BN1 | Oxidation | Cytochrome P450 | Solanum lycopersicum | Spermatophyta | CYP71BN1 catalyzes the two-step oxidation of lycosantalene to lycosantalonol | |
| MITE0000092 | BorH | Halogenation | Flavin-dependent halogenase | uncultured bacterium | Not found | Tryptophan-6 halogenation | |
| MITE0000093 | PhmJ | Halogenation | FAD-dependent halogenase | Leptolyngbya sp. ISBN3-Nov-94-8 | Leptolyngbyaceae | PhmJ forms the vinyl bromination in phormidolide A | |
| MITE0000094 | TnmK2 | Dioxygenation | Iterative cofactorless dioxygenase | Streptomyces sp. (strain CB03234) | Streptomycetaceae | N/A | |
| MITE0000095 | TnmK1 | Cyclization | Hydrolase | Streptomyces sp. (strain CB03234) | Streptomycetaceae | Catalyzes D-ring-forming Michael addition | |
| MITE0000096 | TnmJ | Dioxygenation | Cofactorless oxygenase | Streptomyces sp. CB03234 | Streptomycetaceae | N/A | |
| MITE0000097 | PumI | Dehydrogenation | Oxidoreductase | Streptomyces sp. | Streptomycetaceae | Dehydrogenates (oxidates) pseudouridine in the pseudouridimycin pathway. | |
| MITE0000098 | PumK | Other | Carboxylate-amine ligase | Streptomyces sp. | Streptomycetaceae | Transfers glutamine to 5'-aminopseudouridine in pseudouridimycin pathway. | |
| MITE0000099 | PumJ | Other | Pseudouridine synthase | Streptomyces sp. | Streptomycetaceae | N/A | |
| MITE0000100 | PumG | Amination | Aminotransferase | Streptomyces sp. | Streptomycetaceae | Performs amination of 5'-oxo-pseudouridine in the pseudouridimycin pathway. | |
| MITE0000101 | Cxm5 | Heterocyclization | Cytochrome P450 | Actinoplanes tsinanensis | Micromonosporaceae | N/A | |
| MITE0000102 | TrlE | Other | Flavoprotein monooxygenase | Streptomyces cyaneofuscatus | Streptomycetaceae | Combines hydroxylation, decarboxylation and oxidation to generate tropol... | |
| MITE0000103 | TrlF | Other | Decarboxylase/Hydrolase | Streptomyces cyaneofuscatus | Streptomycetaceae | Cleaves off CoA from 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA | |
| MITE0000104 | TrlC | Hydroxylation | Oxygenase component of flavoprotein monooxygenase TrlCD | Streptomyces cyaneofuscatus | Streptomycetaceae | Catalyzes hydroxylation from 7-hydroxytropolone to 3,7-dihydroxytropolone | |
| MITE0000105 | GnmP | Methylation | Persulfide methyltransferase | Streptomyces sp. CB01883 | Streptomycetaceae | N/A | |
| MITE0000106 | MstE | Cyclization | Terpene cyclase | Scytonema sp. PCC 10023 | Scytonemataceae | N/A | |
| MITE0000107 | Mca | Hydrolysis | Amidase | Streptomyces cyslabdanicus | Streptomycetaceae | N/A | |
| MITE0000108 | CldC | Oxidation | Cytochrome P450 | Streptomyces cyslabdanicus | Streptomycetaceae | N/A | |
| MITE0000109 | CmxA | Cyclization|Deamination | L-lysine cyclodeaminase | Myxococcus sp. | Cystobacterineae | cyclization and deamination of lysine to pipecolic acid | |
| MITE0000110 | NgnN4 | Other | Proline adenyltransferase | Nocardia argentinensis | Nocardiaceae | NgnN4 is responsible for attaching a pyrrole-moiety. | |
| MITE0000111 | NgnO3 | Other|Oxidation | Dioxygenase | Nocardia argentinensis | Nocardiaceae | NgnO3 catalyzes the formation of the ether bridge moiety at position C8/... | |
| MITE0000112 | Ngnp1 | Hydroxylation|Oxidation | Cytochrome P450 | Nocardia argentinensis | Nocardiaceae | Hydroxylation at c-2 | |
| MITE0000113 | NgnD | Cyclization | Nuclear transport factor 2 family protein | Nocardia argentinensis | Nocardiaceae | [6+4] cycloaddition; NgnD acts likely similar to a bispericyclase | |
| MITE0000114 | NgnM | Methylation | O-methyltransferase | Nocardia argentinensis | Nocardiaceae | NgnM methylates the hydroxyl group at the 2-position of the macrolactone... | |
| MITE0000115 | NgnP2 | Hydroxylation|Monooxygenation|Oxidation | Cytochrome P450 | Nocardia argentinensis | Nocardiaceae | Hydroxylation at C-18 | |
| MITE0000116 | StoC | Dehydration | NADPH-dependent oxidoreductase | Pseudomonas fluorescens | Pseudomonadaceae | Dehydration; elimination of primary alcohol under formation exo-methylene group | |
| MITE0000117 | StoR | Reduction | NADPH-dependent oxidoreductase | Pseudomonas fluorescens | Pseudomonadaceae | NADPH dependent reduction of exo-methylene in styrolide B to methyl grou... | |
| MITE0000118 | AcaR | Reduction | NADPH-dependent oxidoreductase | Pseudomonas jessenii | Pseudomonadaceae | reduction of exocxclic double bond in dehydroacaterin to acaterin | |
| MITE0000119 | ScyL2 | Hydroxylation | AsaB-like alphaKGDD | Scytalidium album | Leotiomycetes | Hydroxylation of deoxyscytalidin C6 to scytalidin | |
| MITE0000120 | ZopL9/ZopK | Hydroxylation|Ring contraction | AsaB-like alphaKGDD | Diffractella curvata | Sordariomycetes | Catalyzes a ring contraction of the nine-membered central ring to yield ... | |
| MITE0000121 | AbmB | Hydroxylation | L-Ornithine N(5)-oxygenase | Streptomyces sp. ATCC 700974 | Streptomycetaceae | N-hydroxylation of delta-amine of ornithin | |
| MITE0000122 | AbmA | Acetylation | Acetyltransferase | Streptomyces sp. ATCC 700974 | Streptomycetaceae | N/A | |
| MITE0000123 | JuiM | Acetylation | Acetyltransferase | Streptomyces sampsonii | Streptomycetaceae | Acetylates the nascent julichrome monomer | |
| MITE0000124 | JuiL | Reduction | F420-dependent oxidoreductase | Streptomyces sampsonii | Streptomycetaceae | N/A | |
| MITE0000125 | JuiI | Biaryl bond formation | Cytochrome P450 | Streptomyces sampsonii | Streptomycetaceae | Biaryl coupling of two julichrome Q6 units | |
| MITE0000126 | AetF | Halogenation | Flavin-dependent halogenase | Aetokthonos hydrillicola Thurmond2011 | Hapalosiphonaceae | Bromination of L-tryptophan, leading to 5-bromotryptophan | |
| MITE0000127 | AetA | Halogenation | Flavin-dependent halogenase | Aetokthonos hydrillicola Thurmond2011 | Hapalosiphonaceae | Bromination of 5-bromoindole, leading to 3,5-tribromoindole | |
| MITE0000128 | OrfA | Halogenation | Halogenase | Streptomyces tumemacerans | Streptomycetaceae | FADH2-dependent halogenase in the biosynthesis of chloroalbofungin | |
| MITE0000129 | ThnJ | Deamination | Aminotransferase | Streptomyces sp. FXJ1.172 | Streptomycetaceae | N/A | |
| MITE0000130 | ThnH | Halogenation | Tryptophan 6-halogenase | Streptomyces sp. FXJ1.172 | Streptomycetaceae | chlorinates tryptophan to form 6-Cl-tryptophan (6-Cl-Trp) | |
| MITE0000131 | ThnA | Amination | Amidotransferase | Streptomyces sp. FXJ1.172 | Streptomycetaceae | N/A | |
| MITE0000132 | THAA2 | Acetylation | Acetyltransferase | Arabidopsis lyrata subsp. lyrata | Spermatophyta | O-acetylation as final step of the thalianin pathway in Arabidopsis thal... | |
| MITE0000133 | THAH | Hydroxylation | Cytochrome P450 | Arabidopsis lyrata subsp. lyrata | Spermatophyta | Hydroxylates the intermediate in the thalianin pathway in Arabidopsis th... | |
| MITE0000134 | THAS | Cyclization | Oxidosqualene cyclase | Arabidopsis lyrata | Spermatophyta | Cyclases the intermediate in the thalianin pathway in Arabidopsis thalia... | |
| MITE0000135 | THAO | Hydroxylation | Cytochrome P450 | Arabidopsis lyrata subsp. lyrata | Spermatophyta | Hydroxylates the intermediate in the thalianin pathway in Arabidopsis th... | |
| MITE0000136 | THAA1 | Acetylation | Acyltransferase subfamily IIIa | Not found | Not found | Acetylates the intermediate in the thalianin pathway in Arabidopsis thal... | |
| MITE0000137 | AnkG | Other | ATP-grasp protein | Aspergillus thermomutatus | Eurotiomycetes | N/A | |
| MITE0000138 | AnkE | Other | NRPS independent siderophore synthetase | Aspergillus thermomutatus | Eurotiomycetes | N/A | |
| MITE0000139 | AnkD | Other | Pyridoxal-phosphate dependent enzyme | Aspergillus thermomutatus | Eurotiomycetes | N/A | |
| MITE0000141 | AnkF | Methylation | O-methyltransferase | Aspergillus thermomutatus | Eurotiomycetes | N/A | |
| MITE0000142 | AnkC | Monooxygenation | FAD-dependent monooxygenase | Aspergillus thermomutatus | Eurotiomycetes | N/A | |
| MITE0000143 | AvaC | Hydrolysis | Kynurenine formamidase | Aspergillus versicolor | Eurotiomycetes | N/A | |
| MITE0000144 | AvaB | Monooxygenation | FAD-dependent monooxygenase | Aspergillus versicolor | Eurotiomycetes | N/A | |
| MITE0000145 | AvaD | Acetylation | GNAT family N-acetyltransferase | Aspergillus versicolor | Eurotiomycetes | Acetylates the arginine of the diketopiperazine substrate | |
| MITE0000147 | PeuJ | Hydroxylation | FMN-dependent monooxygenase | Streptomyces peucetius subsp. caesius ATCC 27952 | Streptomycetaceae | N/A | |
| MITE0000149 | MciB | Biaryl bond formation | Cytochrome P450 | Micromonospora citrea | Micromonosporaceae | Macrocyclisation of Tyr-Trp via biaryl bond formation. | |
| MITE0000150 | CYP158C1 | Biaryl bond formation | Cytochrome P450 | Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) | Streptomycetaceae | N/A | |
| MITE0000151 | PspC | Oxidation | Cytochrome P450 | Penicillium soppii | Eurotiomycetes | catalyzes three-step oxidations at the C-4 methyl group to carboxylic ac... | |
| MITE0000152 | ScnB | Biaryl bond formation | Cytochrome P450 | Streptomyces sp. CNQ-509 | Streptomycetaceae | Installs biaryl crosslink between trp-trp | |
| MITE0000153 | SgrB | Biaryl bond formation | Cytochrome P450 | Not found | Not found | Installs biaryl crosslink between his-his | |
| MITE0000154 | PeuJ | Hydroxylation | Monooxygenase | Streptomyces seoulensis | Streptomycetaceae | Monooxygenase | |
| MITE0000155 | SrsB | Methylation | O-methyltransferase | Streptomyces griseus subsp. griseus NBRC 13350 | Streptomycetaceae | O-methylation of alkylresorcinols to yield alkylresorcinol methyl ethers | |
| MITE0000156 | PhoM | Monooxygenation | Flavin-dependent monooxygenase | Diaporthe sp. | Sordariomycetes | The monooxygenase PhoM is involved in C5 hydroxlation during biosynethes... | |
| MITE0000157 | PhoL | Reduction | Short-chain dehydrogenases/reductase | Diaporthe sp. | Sordariomycetes | PhoL is responsible for reduction of monodictyphenone towards the biosyn... | |
| MITE0000158 | PhoJ | Dioxygenation | Dioxygenase | Diaporthe sp. | Sordariomycetes | PhoJ is a dioxygenase involved in a ring-opening strategy to form monodi... | |
| MITE0000159 | PhoD | Dehydration | Dehydratase | Diaporthe sp. | Sordariomycetes | PhoD is a dehydratase responsible for the formation of the intermediate ... | |
| MITE0000160 | PhoC | Reduction | Short-chain dehydrogenases/reductase | Diaporthe sp. | Sordariomycetes | PhoD is a reductase responsible for the reduction of a double bond durin... | |
| MITE0000161 | PhoK | Acetylation|Reduction | Reductase | Diaporthe sp. | Sordariomycetes | N/A | |
| MITE0000162 | PhoG | Oxidation | Anthrone oxygenase | Diaporthe sp. | Sordariomycetes | Responsible for the conversion of emodin anthrone to emodin by oxidation... | |
| MITE0000163 | PhoH | Decarboxylation | Decarboxylase | Diaporthe sp. | Sordariomycetes | Decarboxylase responsible for the conversion of atrochrysone carboxylic ... | |
| MITE0000164 | PhoP | Reduction | Short-chain dehydrogenases/reductase | Diaporthe sp. | Sordariomycetes | PhoP is a short-chain dehydrogenases/reductase responsible for a reducti... | |
| MITE0000165 | PhoN | Other | Isomerase | Diaporthe sp. | Sordariomycetes | N/A | |
| MITE0000166 | ProsF | Methylation | O-methyltransferase | Phaeosphaeria sp. | Dothideomycetes | SAM (S-adenosyl-L-methionine)-dependent O-methylation of roseopurpurin i... | |
| MITE0000167 | ProsD | Hydrolysis | Glyoxalase | Phaeosphaeria sp. | Dothideomycetes | Ring cleavage in the scope of detoxification. | |
| MITE0000168 | ProsA | Oxidation | Cytochrome P450 | Phaeosphaeria sp. | Dothideomycetes | ProsA works in concert with SDR ProsC to yield the pathway intermediate.... | |
| MITE0000169 | ProsC | Reduction | Short-chain dehydrogenase/reductase | Phaeosphaeria sp. | Dothideomycetes | ProsC works in concert with P450 ProsA to yield the pathway intermediate... | |
| MITE0000170 | ProsK | Cyclization | Cytochrome P450 | Phaeosphaeria sp. | Dothideomycetes | Depside bond formation by oxidative ether formation. | |
| MITE0000171 | ProsB | Decarboxylation | Decarboxylase | Phaeosphaeria sp. | Dothideomycetes | Decarboxylates the phenolic substrate | |
| MITE0000172 | LauB1 | Biaryl bond formation | Cytochrome P450 | Streptomyces laurentii | Streptomycetaceae | Installs biaryl crosslinks | |
| MITE0000173 | ScaB aka EmbB | Biaryl bond formation | Cytochrome P450 | Streptomyces sp. SID5474 | Streptomycetaceae | W-W biaryl crosslink formation | |
| MITE0000174 | BytO | Biaryl bond formation | Cytochrome P450 | Planomonospora sp | Streptosporangiaceae | Introduces a biaryl bond between Y1 and H3, cytochrome P450 from Planomo... | |
| MITE0000175 | BytO | Biaryl bond formation | Cytochrome P450 | Planomonospora sp | Streptosporangiaceae | Biaryl formation between Y1 and H3 of the tripeptide, cytochrome P450, P... | |
| MITE0000176 | Ple1 | Hydroxylation | Cytochrome P450 | Rhodocybe pseudopiperita | Agaricomycetes | Hydroxylation, Ple1 catalyzed hydroxylation on the α position of the ace... | |
| MITE0000177 | Ple2 | Acetylation | Acetyltransferase | Rhodocybe pseudopiperita | Agaricomycetes | Acetylation, O-acetylation of mutilin to produce 14-acetyl-mutilin | |
| MITE0000178 | Ple6 | Hydroxylation | Cytochrome P450 | Rhodocybe pseudopiperita | Agaricomycetes | Hydroxylation | |
| MITE0000179 | Ple5/PLE5_RHOPP | Hydroxylation | Cytochrome P450 | Rhodocybe pseudopiperita | Agaricomycetes | Hydroxylation | |
| MITE0000180 | SLI_0884 | Other | Leucyl/Phenylalanine-tRNA-protein transferase | Streptomyces lividans 1326 | Streptomycetaceae | amide bond formation between arginine, encoded by the A domain of the NR... | |
| MITE0000181 | FrsC | Reduction | Dehydrogenase | Chromobacterium vaccinii | Chromobacteriaceae | Reduction of phenylpyruvate to L-phenyllactate | |
| MITE0000182 | SxtN | Sulfonation | N-sulfotransferase | Heteroscytonema crispum UCFS15 | Heteroscytonemataceae | N-sulfonation of saxitoxin | |
| MITE0000183 | EryK | Hydroxylation | Cytochrome P450 | Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) | Pseudonocardiaceae | C-12 hydroxylation of erythromycin B to form erythromycin A | |
| MITE0000184 | RufO | Other | Cytochrome P450 | Streptomyces atratus | Streptomycetaceae | direct nitration of tyrosine in MRYLH pentapeptide | |
| MITE0000185 | FrsH | Hydroxylation | Non-heme diiron monooxygenase | Chromobacterium vaccinii | Chromobacteriaceae | beta-hydroxylation of PCP-bound leucine | |
| MITE0000186 | HrmF | Other | L-DOPA dioxygenase | Streptomyces griseoflavus | Streptomycetaceae | extradiol cleavage of L-DOPA, rearrangement to alkylproline derivative | |
| MITE0000187 | HrmI | Oxidation | Heme oxygenase-like dinuclear iron enzyme | Streptomyces griseoflavus | Streptomycetaceae | oxidation of lysine to nitronorleucine | |
| MITE0000188 | BorI | Dehydration|Hydroxylation|Oxidation | Cytochrome P450 | Streptomyces parvulus | Streptomycetaceae | Oxidation of 12-C hydroxyl group of pre-borrelidin to a carbonyl | |
| MITE0000189 | BorJ | Amination | Aminotransferase | Streptomyces parvulus | Streptomycetaceae | Replaces 12-C carbonyl with primary amine on the pre-borrelidin intermediate | |
| MITE0000190 | AurH | Oxidation | Cytochrome P450 | Streptomyces thioluteus | Streptomycetaceae | Oxidation leads to furan-formation | |
| MITE0000191 | PatG | Decarboxylation | Decarboxylase | Penicillium expansum | Eurotiomycetes | Decarboxylation of 6-methylsalicylic in the patulin biosynthetic pathway | |
| MITE0000192 | CtoA | Halogenation | Halogenase | Sorangium cellulosum | Polyangiaceae | Dichlorination of chlorotonil precursor. | |
| MITE0000193 | AlbA | Dehydrogenation | Cyclic dipeptide oxidase | Streptomyces noursei | Streptomycetaceae | Dehydrogenates cyclo(L-Phe-L-Leu) in the scope of the albonoursin biosyn... | |
| MITE0000194 | PhoO | Biaryl bond formation | Cytochrome P450 | Diaporthe sp. | Sordariomycetes | PhoO dimerizes penexanthone B to phomoxanthone A | |
| MITE0000195 | HrmJ | Other | Alpha-ketoglutarate-dependent dioxygenase | Streptomyces griseoflavus | Streptomycetaceae | cyclopropanation (nitronorleucine - nitrocyclopropylalanine) | |
| MITE0000196 | HynE | Hydroxylation | Alpha-ketoglutarate-dependent dioxygenase | Lysobacter sp. K5869 | Lysobacteraceae | beta-hydroxylation of PCP-bound asparagine (anti) | |
| MITE0000197 | HynC | Hydroxylation | Non-heme diiron monooxygenase | Lysobacter sp. K5869 | Lysobacteraceae | beta-hydroxylation of PCP-bound tyrosine (syn) | |
| MITE0000198 | PyrH | Halogenation | Flavin-dependent 5-halogenase | Streptomyces rugosporus | Streptomycetaceae | Chlorinates free-floating L-tryptophan exclusively in position 5 | |
| MITE0000199 | NodM | Oxidation | FAD-dependent monooxygenase | Hypoxylon pulicicidum | Sordariomycetes | Single epoxidation | |
| MITE0000200 | NodB | Cyclization | Terpene cyclase | Hypoxylon pulicicidum | Sordariomycetes | Cyclization | |
| MITE0000201 | NodW | Oxidation | Cytochrome P450 | Hypoxylon pulicicidum | Sordariomycetes | Oxidation terminal methyl | |
| MITE0000202 | BraB | Glycosylation | Glycosyltransferase | Annulohypoxylon truncatum | Sordariomycetes | Glycosylation | |
| MITE0000203 | braC | Hydroxylation|Oxidation | Cytochrome P450 | Annulohypoxylon truncatum | Sordariomycetes | Hydroxylation at C-12 | |
| MITE0000204 | AoL1 | Oxidation | Short-chain dehydrogenase/reductase | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | Eurotiomycetes | AoL1 is an SDR responsible for converting 8-hydroxy aristolochene to 8-o... | |
| MITE0000205 | XhR1 | Carboxylation|Hydroxylation | Cytochrome P450 | Xylaria hypoxylon | Sordariomycetes | Hydroxylation of isopropenyl side chain of aristolochene. | |
| MITE0000206 | AoL4 | Hydroxylation | Cytochrome P450 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | Eurotiomycetes | AoL4 is a P450 responsible for converting aristolochene to 8-hydroxy ari... | |
| MITE0000207 | LrcB1 | Hydrolysis | Peptidase Subunit | Paenibacillus sp. M2 | Paenibacillaceae | N-terminal cleavage of leader peptide, resulting in immature intermediat... | |
| MITE0000208 | LrcF | Hydrolysis | Peptidase, clostripain-family | Paenibacillus sp. M2 | Paenibacillaceae | C-terminal cleavage of glycin from lassopeptide | |
| MITE0000209 | LrcC | Macrolactam formation | Macrolactam synthetase | Paenibacillus sp. M2 | Paenibacillaceae | Lassopeptide macrolactam formation after N-terminal cleavage | |
| MITE0000210 | CheE | Monooxygenation | Cytochrome P450 | Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) | Sordariomycetes | Stereoselective epoxidation of the olefin at C6-7 in the chaetoglobosin ... | |
| MITE0000211 | PyiA | Methylation | O-methyltransferase | Pyricularia grisea | Sordariomycetes | Methylation of L-tyrosine | |
| MITE0000212 | TalC | Glycosylation | Deoxysugar transferase | Streptomyces mozunensis | Streptomycetaceae | Glycosylation of phosphoramidon peptidic intermediate with L-rhamnose | |
| MITE0000213 | TalE | Phosphorylation | Kinase | Streptomyces mozunensis | Streptomycetaceae | Install an N-terminal phosphoramidate on peptidic substrate | |
| MITE0000214 | LsGAO1 | Oxidation | Cytochrome P450 | Lactuca sativa | Spermatophyta | Converts germacrene A to germacrene A acid via three-step oxidation | |
| MITE0000215 | CiLCS | Hydroxylation | Cytochrome P450 | Cichorium intybus | Spermatophyta | Converts 8-deoxylactucin to lactucin | |
| MITE0000216 | ShyB | Biaryl bond formation | Cytochrome P450 | Streptomyces clavuligerus | Streptomycetaceae | Biaryl bond formation between H-Y | |
| MITE0000217 | ChtnH | Other | Pyruvyl transferase | Chitinimonas sp. | Chitinibacteraceae | Pyruvylation of a PUFA synthase-derived alkyl chain via reaction with a ... | |
| MITE0000218 | CYP502B15 | Hydroxylation | Cytochrome P450 | Trametes versicolor | Agaricomycetes | Modifies various cadinane-type sesquiterpenoids | |
| MITE0000219 | BipD | Biaryl bond formation | B12-containing rSAM | Peribacillus simplex | Bacillaceae | Introduction of biaryl-bond between two ortho-tyrosine residues | |
| MITE0000220 | MlaO | Hydroxylation | Hydroxylation | Streptomyces sp. MP39-85 | Streptomycetaceae | Hydroxylation of polyene macrolide scaffold to yield ML-449 in Streptomy... | |
| MITE0000221 | BecO | Hydroxylation | Hydroxylation | Streptomyces sp. DSM 21069 | Streptomycetaceae | Hydroxylation of polyene macrolide scaffold to yield BE-14106 in Strepto... | |
| MITE0000222 | CcsB | Monooxygenation|Oxidation | Baeyer-Villiger monooxygenase | Aspergillus clavatus | Eurotiomycetes | Oxidative generation of in-line carbonate functional group | |
| MITE0000223 | AgcF | Prenylation | Guanidine prenyltransferase | Microcystis aeruginosa | Chroococcales | N-prenylation on guanidine moiety of arginine residue of Argicyclamide C | |
| MITE0000224 | AgeMTPT | Methylation|Prenylation | Bifunctional prenyltransferase/methyltransferase | Microcystis aeruginosa PCC 9432 | Chroococcales | Prenylation and Methyl esterification at free N- and C-termini of linear... | |
| MITE0000225 | ArbB2 | Cyclization | Burpitide cyclases/BURP-domain peptide cyclases | Not found | Not found | Macrocyclisation of Tyr-phenol-O to Leu-Cβ bond observed in arabipeptin ... | |
| MITE0000226 | StmC | Glycosylation | Glycosyltransferase | Aspergillus ustus | Eurotiomycetes | Glycosylation of stromemycin in Aspergillus ustus | |
| MITE0000227 | AprY | Oxidation | Oxidase | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Oxidative cyclization of Y2 and Y6 in the FYYTGY hexapeptide, no leader ... | |
| MITE0000228 | LlpCT | Acylation | Crotonobetainyl-CoA:carnitine CoA-transferase | Streptomyces yunnanensis | Streptomycetaceae | Transfers different Acyl-CoAs onto tyrosine; reaction shown for yunnansi... | |
| MITE0000229 | GelC | Macrolactam formation | Macrolactam synthetase | Not found | Not found | Lasso macrocyclisation of gelatinamin intermediate after leader peptide ... | |
| MITE0000230 | GelB2 | Hydrolysis | Peptidase | Not found | Not found | N-terminal cleavage of gelatinamin leader peptide, resulting in immature... | |
| MITE0000231 | GelP | Cyclization | Transpeptidase, clostripain-like | Not found | Not found | Introduction of second macrocylce on lassopeptide via hydrolysis of C-te... | |
| MITE0000232 | GelT | Acetylation | Acetyltransferase | Not found | Not found | Acetylation of single C-terminal lysin of gelatinamin B to prevent auto-... | |
| MITE0000233 | NisB | Dehydration | Dehydratase | Lactococcus lactis subsp. lactis | Streptococcaceae | Dehydration of ser/thr in nisin A precursor peptide. Leader peptide with... | |
| MITE0000234 | NisC | Cyclization | Lanthionine synthetase | Lactococcus lactis subsp. lactis | Streptococcaceae | (Methyl-)lanthionine formation between dehydrated Ser/Thr and Cys on nis... | |
| MITE0000235 | NisP | Hydrolysis | Protease | Lactococcus lactis subsp. lactis | Streptococcaceae | Cleavage of nisin precursor peptide (prepeptide) by recognizing the GASP... | |
| MITE0000236 | BesE | Hydroxylation | Hydroxylase | Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) | Streptomycetaceae | Hydroxylates intermediate in beta-ethynylserine pathway, showing high su... | |
| MITE0000237 | PtmC | Cyclization|Reduction | Alcohol dehydrogenase/reductase | Streptomyces pactum | Streptomycetaceae | Reductive cyclization to form a 6-membered ring in pactamide pathway. | |
| MITE0000238 | CftD | Cyclization|Reduction | Alcohol dehydrogenase/reductase | Kitasatospora sp. | Streptomycetaceae | Reductive cyclization to form a 5-membered ring. | |
| MITE0000239 | IkaC | Cyclization|Reduction | Alcohol dehydrogenase/reductase | Streptomyces sp. ZJ306 | Streptomycetaceae | Reductive cyclization to form a 5-membered ring in ikarugamycin pathway. | |
| MITE0000240 | OX4 | Cyclization|Reduction | Alcohol dehydrogenase/reductase | Lysobacter enzymogenes | Lysobacteraceae | Reductive cyclization to form a 6-membered ring. | |
| MITE0000241 | TolF | Prenylation | O-prenyltransferase | Tolypothrix sp. PCC 7601 | Tolypothrichaceae | Forward O-prenylation of threonine residue of precursor peptide to yield... | |
| MITE0000242 | TamI | Hydroxylation|Other | Cytochrome P450 | Streptomyces sp. 307-9 | Streptomycetaceae | Hydroxylation of tirandamycin C as first tailoring step in the tirandamy... | |
| MITE0000243 | TamL | Oxidation | FAD-dependent oxidase | Streptomyces sp. 307-9 | Streptomycetaceae | TamL oxidizes the C-10 hydroxy to a keton in the tirandamycin biosynthet... | |
| MITE0000244 | NotF | Prenylation | Deoxybrevianamide E synthase | Aspergillus sp. (strain MF297-2) | Eurotiomycetes | Reverse prenylation of brevianamide F in the notoamid pathway, with high... | |
| MITE0000245 | NotG | Hydroxylation | Cytochrome P450 | Aspergillus sp. (strain MF297-2) | Eurotiomycetes | Hydroxylation of deoxybrevianamide E in notoamide biosynthetic pathway. | |
| MITE0000246 | NotC | Prenylation | Prenyltransferase | Aspergillus sp. (strain MF297-2) | Eurotiomycetes | Aromatic prenylation of tryptophan-moiety of 6-OH deoxybrevianamide E in... | |
| MITE0000247 | NotB | Cyclization|Monooxygenation | FAD-dependent monooxygenase | Aspergillus sp. (strain MF297-2) | Eurotiomycetes | Oxidative cyclisation of the notoamide E oxidase in the notoamide pathwa... | |
| MITE0000248 | PenDE | Acylation | Acyl-CoA:isopenicillin N N-acyltransferase | Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) | Eurotiomycetes | Transacylation of side chain of isopenicillin N in the biosynthetic path... | |
| MITE0000249 | PcbC | Cyclization | Isopenicillin N synthase | Penicillium chrysogenum | Eurotiomycetes | Cyclization of the ACV substrate to isopenicillin N in the biosynthetic ... | |
| MITE0000250 | DynA | Cyclization | Radical SAM enzyme | Photorhabdus australis subsp. thailandensis | Morganellaceae | Macrocyclization of DynB precursor peptide. Available information indica... | |
| MITE0000251 | KwwB | Biaryl bond formation | Cytochrome P450 | Not found | Not found | Biaryl formation between Trp-C5 and Trp-N1 at the WxW motif; enzyme has ... | |
| MITE0000252 | NosB | Hydroxylation | Cytochrome P450 | Streptomyces actuosus | Streptomycetaceae | NosB hydroxylates the gamma-position of Glu6 in the nosiheptide biosynth... | |
| MITE0000253 | NosA | Other | Terminal amide synthase | Streptomyces actuosus | Streptomycetaceae | NosA cleaves C-alpha-N bond of terminal enamine in nosiheptide maturatio... | |
| MITE0000254 | NosC | Hydroxylation | Cytochrome P450 | Streptomyces actuosus | Streptomycetaceae | Hydroxylates the pyridin moiety of the nascent nosiheptide intermediate | |
| MITE0000255 | NosO | Cyclization | Pyridine synthase | Streptomyces actuosus | Streptomycetaceae | Introduction of 23-membered main macrocyclic ring system in nosiheptide ... | |
| MITE0000256 | NosN | Cyclization|Methylation | Radical SAM enzyme | Streptomyces actuosus | Streptomycetaceae | Completion of 19-membered side ring system in nascent nosiheptide by C1 ... | |
| MITE0000257 | NosE | Dehydration | Dehydratase | Streptomyces actuosus | Streptomycetaceae | Dehydratation of Ser/Thr residues to Dha/Dhb in the biosynthetic pathway... | |
| MITE0000258 | NosK | Other | Alpha/beta-hydrolase fold protein | Streptomyces actuosus | Streptomycetaceae | Attaches 3-methyl-2-indolic acid (MIA) via through S-MIAylation to Cys8 ... | |
| MITE0000259 | NosF | Dehydrogenation | Dehydrogenase | Streptomyces actuosus | Streptomycetaceae | Dehydrogenation of thiazolines to thiazoles in nosiheptide pathway. Curr... | |
| MITE0000260 | NosG | Dehydration|Heterocyclization | E1-YcaO didomain protein | Streptomyces actuosus | Streptomycetaceae | Cyclodehydration of cystein-thiol with preceding peptide bond | |
| MITE0000261 | NosL | Carboxylation|Deamination|Decarboxylation | Radical SAM enzyme | Streptomyces actuosus | Streptomycetaceae | 3-methyl-2-indolic acid (MIA) synthase involved in nosiheptide biosynthesis | |
| MITE0000262 | TxtE | Other | Cytochrome P450 | Streptomyces scabiei (strain 87.22) | Streptomycetaceae | Nitrates free-floating L-tryptophan as the first committed step in the t... | |
| MITE0000263 | WgkB | Cyclization | Radical SAM enzyme | Not found | Not found | Forms two C–C bonds in the precursor peptide WgkA: Trp18-C5 to Lys20-Cα ... | |
| MITE0000264 | KtnB | Methylation | O-Methyltransferase | Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513) | Eurotiomycetes | Methylation of 4,7-O-didemethylsiderin into 7-O-demethylsiderin | |
| MITE0000265 | KtnC | Biaryl bond formation | Cytochrome P450 | Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513) | Eurotiomycetes | Regio- and stereoselective oxidative phenolic coupling of 7-demethylside... | |
| MITE0000266 | DesC | Biaryl bond formation | Cytochrome P450 | Aspergillus desertorum | Eurotiomycetes | Regio- and stereoselective oxidative phenolic coupling of 7-demethylside... | |
| MITE0000267 | AfvE | Biaryl bond formation | Cytochrome P450 | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Oxidative phenolic coupling of siderin monomers forming the bicoumarin 3... | |
| MITE0000268 | AntC | Glycosylation | Glycosyltransferase | Pseudonocardia alni | Pseudonocardiaceae | Transfer of two vancosamine moieties to the C-13 and C-13' positions of ... | |
| MITE0000269 | AntD | Glycosylation | Glycosyltransferase | Pseudonocardia alni | Pseudonocardiaceae | Transfer of β-D-glucose to the C-24 hydroxyl of one α-L-vancosamine moie... | |
| MITE0000270 | Luc1 | Methylation | Methyltransferase | Fusarium sp | Sordariomycetes | demethyllucilactaene to Lucilactaene by the methyltransferase Luc1 | |
| MITE0000271 | Luc3 | Dehydrogenation | Aldehyde dehydrogenase | Fusarium sp | Sordariomycetes | Luc3 is involved in the biosynthesis by further oxidation of the C-20 al... | |
| MITE0000272 | Luc2 | Monooxygenation|Other | Cytochrome P450 | Fusarium sp | Sordariomycetes | Luc2 oxidizes the C-20, but Luc3 is required for the full oxidation of ... | |
| MITE0000273 | DarH | Halogenation | Halogenase | Pseudoalteromonas luteoviolacea H33 | Pseudoalteromonadaceae | Bromination of C-8 of W1 of darobactin A, yielding bromodarobactin A. | |
| MITE0000274 | MppC | Reduction | NAD(P)H-dependent oxidoreductase | Monascus pilosus | Eurotiomycetes | proposed reduction and isomerization - NAD(P)H-dependent oxidoreductase | |
| MITE0000275 | MppB | Acylation | acyltransferase | Monascus pilosus | Eurotiomycetes | Transferring the acyl group on the pyranoquinone | |
| MITE0000276 | Mpp7 | Dehydration | Dehydratase | Monascus pilosus | Eurotiomycetes | Mpp7 controls regioselective Knoevenagel condensation | |
| MITE0000277 | LtxC | Prenylation | Prenyltransferase / Geranyl transferase | Lyngbya majuscula | Oscillatoriales | Prenyltransferase / Geranyl transferase | |
| MITE0000278 | LtxB | Cyclization|Oxidation | Cytochrome P450 | Lyngbya majuscula | Oscillatoriales | Oxidative cyclization | |
| MITE0000279 | SenA | Other | Selenoneine synthase | Variovorax paradoxus | Comamonadaceae | Oxidative C–Se bond formation between hercynine and SeGlcNAc, yielding a... | |
| MITE0000280 | RufB | Hydrolysis | Aminopeptidase | Streptomyces atratus | Streptomycetaceae | Cleavage of BytA to afford 3-NO2-Tyr | |
| MITE0000281 | RufO | Monooxygenation | Cytochrome P450 | Streptomyces atratus | Streptomycetaceae | Oxidative nitration of tyrosine using NO | |
| MITE0000282 | DovE | Monooxygenation|Oxidation | Cytochrome P450 | Penicillium decumbens | Eurotiomycetes | Regioselective epoxidation of the 2,5-dihydrofuran moiety. | |
| MITE0000283 | DovD | Cyclization|Ring expansion | Epoxide expandase (Cyclase) | Penicillium decumbens | Eurotiomycetes | Conversion of a 10,11-epoxide polyene intermediate into a tetrahydrofura... | |
| MITE0000284 | DovC | Monooxygenation|Oxidation | Flavin-containing monooxygenase (FMO) | Penicillium decumbens | Eurotiomycetes | Regioselective epoxidation at the C10–C11 position of the deoxyverrucosi... | |
| MITE0000285 | UstD | Decarboxylation|Other | PLP-dependent enzyme | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Production of ustiloxin B via condensation of an aldehyde intermediate w... | |
| MITE0000286 | UstF2 | Decarboxylation|Dehydration|Hydroxylation | Flavin-containing monooxygenase | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Conversion of ustiloxin H to its oxime-derivative through two sequential... | |
| MITE0000287 | UstF1 | Oxidation | Flavin-containing monooxygenase | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | oxidation of the S to S=O | |
| MITE0000288 | UstC | Other | Cytochrome P450 | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Oxidative coupling of a cysteine residue to the phenyl ring (C-S bond formation) | |
| MITE0000289 | UstM | Methylation | N-Methyltransferase | Aspergillus flavus NRRL3357 | Eurotiomycetes | N-methylation of N-desmethylustiloxin F to ustiloxin F | |
| MITE0000290 | PtmT3 | Cyclization | type I diterpene synthase | Streptomyces platensis | Streptomycetaceae | PtmT3, a type I diterpene synthase, was determined to be a (16R)-ent-kau... | |
| MITE0000291 | JadS | Glycosylation | O-Glycosyltransferase | Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) | Streptomycetaceae | Transfer of L-digitoxose to the aglycone of jadomycin B from an NDP-L-di... | |
| MITE0000292 | RslO5 | Reduction | FMN-dependent reductase | Streptomyces bottropensis | Streptomycetaceae | FMN-dependent reductive epoxide opening of intermediate from the rishiri... | |
| MITE0000293 | AnuE | Hydroxylation|Monooxygenation | Cytochrome P450 | Penicillium roqueforti (strain FM164) | Eurotiomycetes | Hydroxylation of an intermediate from the biosynthesis of Annullatin D. | |
| MITE0000294 | LepF | Reduction | Short chain dehydrogenase/reductase | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Reduction of a ketone intermediate to a secondary alcohol in the leporin... | |
| MITE0000295 | CYPArm2 | Hydroxylation|Monooxygenation | Cytochrome P450 | Armillaria gallica | Agaricomycetes | Protoilludene 13-hydroxylation in the biosynthesis of armillyl orsellina... | |
| MITE0000296 | CylC | Halogenation | Halogenase | Cylindrospermum licheniforme UTEX B 2014 | Nostocaceae | halogenates sp3-carbons of ACP-bound fatty acids | |
| MITE0000297 | AsaD | Hydroxylation | Cytochrome P450 | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Conversion of deoxyaspergillic acid into aspergillic acid via N-hydroxylation | |
| MITE0000298 | AsaB | Hydroxylation | Hydroxylase | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Hydroxylation of aspergillic acid to hydroxyaspergillic acid | |
| MITE0000299 | avm28 | Hydroxylation | Cytochrome P450 | Streptomyces atrovirens | Streptomycetaceae | Phe β-hydroxylation tailoring enzyme in atrovimycin biosynthesis | |
| MITE0000300 | PbsC | Hydroxylation | Multinuclear nonheme Fe-dependent oxidative enzyme | Peribacillus simplex | Bacillaceae | Hydroxylation of Phe8 and Phe10 residues in PbsA3 precursor peptide | |
| MITE0000301 | FasV | Halogenation | Halogenase | uncultured bacterium | Not found | FasV catalyzes five successive chlorinations in the biosynthesis of naph... | |
| MITE0000302 | PtmO5 | Hydroxylation|Oxidation | Cytochrome P450 | Streptomyces platensis | Streptomycetaceae | PtmO5, a cytochrome P450 monooxygenase, catalyzes the 11S,16S-ether ring... | |
| MITE0000303 | GulG | Hydroxylation | Cytochrome P450 | Pyxidicoccus fallax | Cystobacterineae | Hydroxylation reaction towards gulmirecin. | |
| MITE0000304 | TraB | Hydroxylation|Oxidation | Cytochrome P450 | Penicillium crustosum | Eurotiomycetes | Cytochrome P450 mediated C-H oxidation | |
| MITE0000305 | RusE | Reduction | FAD-linked oxidoreductase | Penicillium roqueforti (strain FM164) | Eurotiomycetes | Reduction of an aldehyde to a hydroxyl moiety | |
| MITE0000306 | RusF | Hydroxylation|Monooxygenation|Oxidation | Cytochrome P450 | Penicillium roqueforti (strain FM164) | Eurotiomycetes | Catalyzes benzylic C-H oxidation to alcohol | |
| MITE0000307 | AspB | Biaryl bond formation|Oxidation | Cytochrome P450 | Streptomyces sp. NRRL S-1868 | Streptomycetaceae | tryptophan dimerization by C-C coupling | |
| MITE0000308 | Cyt1 | Hydroxylation | FAD-dependent monooxygenase | Gnomonia sp | Sordariomycetes | Hydroxylation of acyl dihydroxyphenylacetic acids. | |
| MITE0000309 | SfmCy2 | Deamination | Oxidoreductase | Streptomyces lavendulae | Streptomycetaceae | Deamination of saframycin to give active compound. | |
| MITE0000310 | OpaC2 | Hydroxylation | flavin-dependent monooxygenase — hydroxylase | Aspergillus ustus | Eurotiomycetes | Regio- and stereospecific hydroxylation at the C-3 position of the oxepi... | |
| MITE0000311 | SfmD | Monooxygenation | Heme-containing peroxygenase | Streptomyces lavendulae | Streptomycetaceae | hydroxylating 3-Me-l-Tyr to 3-OH-5-Me-l-Tyr | |
| MITE0000312 | NocO | Halogenation | Halogenase | Nodularia sp. LEGE 06071 | Nodulariaceae | Diiron radical halogenase. | |
| MITE0000313 | Dsd6 | Oxidation | FAD-linked oxidoreductase (Alcohol Oxidase) | Parmelia sp. 050094 | Lecanoromycetes | Oxidation of the C-8 hydroxymethyl group to a formyl (aldehyde) group. | |
| MITE0000314 | Dsd3 | Cyclization|Hydroxylation | Cytochrome P450 monooxygenase | Parmelia sp. 050094 | Lecanoromycetes | Oxidative cyclization (ether bond formation) of a depside to a depsidone. | |
| MITE0000315 | OsCYP99A3 | Hydroxylation|Monooxygenation|Oxidation | 9-beta-pimara-7,15-diene oxidase | Oryza sativa subsp. japonica | Spermatophyta | Oxidation of primaradien/stemoden-oic acid core structure. | |
| MITE0000316 | LepI | Cyclization|Dehydration|Other | SAM-dependent pericyclase | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | Stereoselective dehydration | |
| MITE0000317 | RoyL | Acylation | Deazapurine amide bond synthetase | Streptomyces filamentosus | Streptomycetaceae | Amide bond between the 7-carboxyl group of 7-carboxy-7-deazaguanine (CDG... | |
| MITE0000318 | SorM | Methylation | O-methyltransferase | Sorangium cellulosum | Polyangiaceae | Responsible for the post-PKS O-methylation of the hydroxyl at C11, from ... | |
| MITE0000319 | LlpH | Halogenation | Non-heme halogenase | Streptomyces tendae | Streptomycetaceae | halogenation | |
| MITE0000320 | XptC | Oxidation | Oxidoreductase | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | Eurotiomycetes | Oxidation reactions of primary alcohol to an aldehyde. | |
| MITE0000321 | LepD | Hydroxylation | Cytochrome P450 | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) | Eurotiomycetes | N-hydroxylation of Leporin C to Leporin B | |
| MITE0000322 | NysL | Hydroxylation|Monooxygenation | monooxygenase / hydroxylase | Streptomyces noursei | Streptomycetaceae | Cytochrome P450 monooxygenase responsible for C10-hydroxylation in last ... | |
| MITE0000326 | MgsK | Hydroxylation | oxidoreductase | Streptomyces platensis subsp. rosaceus | Streptomycetaceae | C-8 hydroxylation of iso-migrastatin core structure | |
| MITE0000327 | MgsI | Reduction | Oxidoreductase | Streptomyces platensis subsp. rosaceus | Streptomycetaceae | MgsI is responsible for enoyl reduction of the C-16/C-17 olefin in iso-m... | |
| MITE0000328 | MgsJ | Methylation | O-Methyltransferase | Streptomyces platensis subsp. rosaceus | Streptomycetaceae | MgsJ is responsible for O-methylation of the HO-C-8 in iso-migrastatin b... | |
| MITE0000329 | AaGAS | Cyclization | Terpene Synthase | Artemisia absinthium | Spermatophyta | Sesquiterpen cyclisation from FPP to Germacrene A | |
| MITE0000330 | PbsE | Other | Arginase | Peribacillus simplex | Bacillaceae | Deguanidination of R9 of dihydroxylated PbsA3 | |
| MITE0000332 | AriF | Cyclization | Cytochrome P450 | Amycolatopsis arida | Pseudonocardiaceae | Formation of tricyclic terpene skeleton by intramolecular cyclization. | |
| MITE0000334 | XszenFHal | Halogenation | Flavid-dependent halogenase | Xenorhabdus szentirmaii DSM 16338 | Morganellaceae | Regiospecific 5-halogenation of L-tryptophan | |
| MITE0000335 | PatH | Hydroxylation | Cytochrome P450 | Penicillium expansum | Eurotiomycetes | Hydroxylation of m-cresol in patulin biosynthetic pathway. | |
| MITE0000336 | AurI | Methylation | O-methyltransferase | Streptomyces thioluteus | Streptomycetaceae | Methylation of hydroxy group on aromatic ring in the aureothin biosynthe... | |
| MITE0000337 | SCO6272 | Monooxygenation | Oxidoreductase | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) | Streptomycetaceae | Catalyse an monooxygenation reaction from compound 4 to compound 5 in th... | |
| MITE0000338 | SCO6279 | Amination | Aminotransferase | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) | Streptomycetaceae | Putatively responsible for amination reaction from compound 3 to compoun... | |
| MITE0000339 | SCO6281 | Monooxygenation | Oxidoreductase | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) | Streptomycetaceae | Putatively responsible for oxygenation of compound 7 to compound 8 in th... | |
| MITE0000340 | FlA1 | Halogenation | Fluorinase | Streptantibioticus cattleyicolor | Streptomycetaceae | Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methioni... | |
| MITE0000341 | MoeH5 | Other | GAT superfamily amidotransferase | Streptomyces viridosporus | Streptomycetaceae | Carboxyamidation of terminal galacturonate of nosokomycin A with ammonia... | |
| MITE0000342 | AriG | Hydroxylation | Cytochrome P450 | Amycolatopsis arida | Pseudonocardiaceae | Hydroxylation of diterpene scaffold | |
| MITE0000343 | TaaH | Hydroxylation | Flavin-dependent S-hydroxylase | Not found | Not found | Hydroxylation of thiocarboxylic acid into sulfenic acid | |
| MITE0000344 | HvfB | Heterocyclization|Oxidation | A multinuclear nonheme iron-dependent oxidase | Haemophilus influenzae (strain 86-028NP) | Pasteurellaceae | Heterocyclization and Oxidation of Cys | |
| MITE0000345 | AuraA | Methylation | Prenyltransferase | Penicillium solitum | Eurotiomycetes | C-prenylation on the imidazole moiety of dihydroviridamine (imidazole-C-... | |
| MITE0000346 | MarG | Cyclization|Heterocyclization|Oxidation | Rieske nonheme iron-dependent oxygenase | Streptomyces sp. CNQ-617 | Streptomycetaceae | Cyclization of 23-hydroxyundecylprodiginine to form the macrocycle and s... | |
| MITE0000347 | PhzF | Other | Isomerase | Pseudomonas fluorescens | Pseudomonadaceae | PhzF catalyzes the isomerization of (2 S,3 S)-2,3-dihydro-3-hydroxy anth... | |
| MITE0000348 | PrnC | Halogenation | Flavin-dependent halogenase | Pseudomonas fluorescens | Pseudomonadaceae | Site-specific chlorination of pyrrolic heterocycles. | |
| MITE0000349 | OpaB | Hydroxylation|Oxidation|Ring expansion | Cytochrome P450 | Aspergillus ustus | Eurotiomycetes | OpaB catalyzes the oxepin ring formation to convert protuboxepin K into ... | |
| MITE0000350 | Ulm24 | Halogenation | Flavin-dependent halogenase | Streptomyces sp. KCB13F003 | Streptomycetaceae | 5-halogenation of L-tryptophan in the ulleungmycin pathway. Exact occurr... | |
| MITE0000351 | AndK | Cyclization|Hydroxylation | Cytochrome P450 | Emericella variicolor | Eurotiomycetes | Hydroxylation as the first step in the anditomin biosynthetic pathway. | |
| MITE0000352 | AndD | Prenylation | Prenyltransferase | Emericella variicolor | Eurotiomycetes | Prenylation as the third step in the anditomin biosynthetic pathway. | |
| MITE0000353 | AndE | Oxidation | FAD-dependent epoxidase | Emericella variicolor | Eurotiomycetes | Epoxidation of farnesyl-DHDMP to give epoxyfarnesyl-DHDMP in the anditom... | |
| MITE0000354 | AndB | Cyclization | Terpene cyclase | Emericella variicolor | Eurotiomycetes | Cyclization of the meroterpenoid intermediate in the anditomin biosynthe... | |
| MITE0000355 | AndC | Oxidation | Dehydrogenase | Emericella variicolor | Eurotiomycetes | Oxidation of meroterpenoid intermediate in the anditomin biosynthetic pathway. | |
| MITE0000356 | AndA | Cyclization|Dehydrogenation | Dioxygenase | Emericella variicolor | Eurotiomycetes | Dehydrogenation of meroterpenoid precursor before cyclization in the and... | |
| MITE0000357 | AndJ | Oxidation|Ring expansion | FAD-dependent Baeyer-Villiger monooxygenase | Emericella variicolor | Eurotiomycetes | Baeyer-Villiger oxidation of meroterpenoid intermediate in the anditomin... | |
| MITE0000358 | AndI | Reduction | Short-chain dehydrogenase | Emericella variicolor | Eurotiomycetes | Reduction of meroterpenoid intermediate in the anditomin biosynthetic pathway. | |
| MITE0000359 | AndG | Acetylation | O-acetyltransferase | Emericella variicolor | Eurotiomycetes | Acetylation of intermediate meroterpenoid in the andilesin biosynthetic pathway. | |
| MITE0000360 | AndH | Reduction | Short-chain dehydrogenase/reductase | Emericella variicolor | Eurotiomycetes | Reduction of meroterpenoid intermediate andilesin B in the andilesin bio... | |
| MITE0000361 | AndF | Dehydrogenation|Dioxygenation|Ring expansion | Dioxygenase | Emericella variicolor | Eurotiomycetes | Oxidative rearrangement as the terminal step in the anditomin biosynthet... | |
| MITE0000362 | salbB | Other | Oxidoreductase | Not found | Not found | SalbB catalyze guaninylation of cyclo-l-Trp-l-Leu (cWL) | |
| MITE0000363 | OpaF | Methylation | O-methyltransferase | Aspergillus ustus | Eurotiomycetes | Catalyzes the conversion of Oxepinamide E to the end product Oxepinamide... | |
| MITE0000364 | CTC2 | Halogenation | Halogenase | Colletotrichum higginsianum (strain IMI 349063) | Sordariomycetes | Chlorination of Colletorin D to produce Colletochlorin D | |
| MITE0000365 | PatD | Reduction | Alcohol dehydrogenase | Penicillium expansum | Eurotiomycetes | ring opening and reduction of neopatulin to E-ascladiol | |
| MITE0000366 | LigK | Ring contraction | Cytochrome P450 | Penicillium paradoxum | Eurotiomycetes | Oxidative ring contraction of a 1,2-dione in the ligustrone biosynthethi... | |
| MITE0000367 | LigI | Methylation | O-methyltransferase | Penicillium paradoxum | Eurotiomycetes | Catalyzes O-methylation of the ring-contracted intermediate in the ligus... | |
| MITE0000368 | AsmK | Monooxygenation | Cytochrome P450 | Streptomyces sp. NA03103 | Streptomycetaceae | Desaturates alanine building block to form a 2-aminoacrylic acid contain... | |
| MITE0000369 | AsmI | Monooxygenation | Monooxygenase | Streptomyces sp. NA03103 | Streptomycetaceae | AsmI is directly involved in the oxidation of the alkene group of benzox... | |
| MITE0000370 | PatE | Cyclization | Patulin synthase | Penicillium expansum | Eurotiomycetes | Conversion of E-ascladiol to patulin | |
| MITE0000371 | SipS13 | Other | Aminotransferase | Streptomyces sp. CS149 | Streptomycetaceae | dTDP-4-dehydro-6-deoxyglucose aminotransferase | |
| MITE0000372 | opaC | Monooxygenation | Monooxygenase | Aspergillus ustus | Eurotiomycetes | opaC is a FAD-containing monooxygenase and could be a good candidate for... | |
| MITE0000373 | OpaB2 | Ring expansion | Cytochrome P450 enzyme (oxepinase) | Aspergillus ustus | Eurotiomycetes | Stereoselective formation of a 1H-oxepin ring from a quinazolinone-conta... | |
| MITE0000374 | AscA | Prenylation | Prenyltransferase | Acremonium egyptiacum | Sordariomycetes | Prenylates orsellinic acid in the ascochlorin/ascofuranone biosynthetic pathway. | |
| MITE0000375 | AscB | Reduction | NRPS-like Oxidoreductase | Acremonium egyptiacum | Sordariomycetes | Reduces ilicicolinic acid B in the ascochlorin/ascofuranone biosynthetic... | |
| MITE0000376 | AscD | Halogenation | Flavin-dependent halogenase | Acremonium egyptiacum | Sordariomycetes | Halogenation of meroterpenoid precursor in the ascochlorin/ascofuranone ... | |
| MITE0000377 | AscE | Oxidation | Cytochrome P450/NADPH P450 reductase | Acremonium egyptiacum | Sordariomycetes | Epoxidation in intermediate meroterpenoid in the ascochlorin/ascofuranon... | |
| MITE0000378 | AscF | Cyclization | Terpene cyclase | Acremonium egyptiacum | Sordariomycetes | Cyclization of intermediate terpenoid in the ascochlorin biosynthetic pathway. | |
| MITE0000379 | AscG | Oxidation | Cytochrome P450 | Acremonium egyptiacum | Sordariomycetes | Oxidation of meroterpenoid precursor in the ascochlorin biosynthetic pat... | |
| MITE0000380 | AscH | Hydroxylation | Cytochrome P450 | Acremonium egyptiacum | Sordariomycetes | Hydroxylation of meroterpenoid intermediate in the ascofuranone biosynth... | |
| MITE0000381 | AscI | Cyclization | Terpene cyclase | Acremonium egyptiacum | Sordariomycetes | Cyclization of meroterpenoid intermediate in the ascofuranone biosynthet... | |
| MITE0000382 | AscJ | Oxidation | Short-chain dehydrogenase/reductase | Acremonium egyptiacum | Sordariomycetes | Oxidizes intermediate meroterpenoid in the ascofuranone biosynthetic pat... | |
| MITE0000383 | GroI | Monooxygenation | Cytochrome P450 | Not found | Not found | GroI incorporates a keto group at C-17 of gromomycin C, leading to the f... | |
| MITE0000384 | Ind7 | Methylation | N-methyltransferase | Streptomyces griseus | Streptomycetaceae | Ind7 (N-methyltransferase) catalyzes the transfer of a methyl group from... | |
| MITE0000385 | PaPT | Prenylation | O-prenyltransferase | Phomopsis amygdali | Sordariomycetes | O-prenylation on glucose moiety of diterpene glycosides intermediates of... | |
| MITE0000386 | PaMT | Methylation | O-Methyltransferase | Phomopsis amygdali | Sordariomycetes | O-methylation of fusicoccin terpene scaffold to yield methylated derivatives. | |
| MITE0000387 | PtmO6 | Oxidation | α-Ketoglutarate-Dependent Dioxygenase | Streptomyces platensis | Streptomycetaceae | stereoselective C7 α-hydroxylation in platensimycin biosynthesis | |
| MITE0000388 | PtmU3 | Oxidation | Nonheme diiron monooxygenase | Streptomyces platensis | Streptomycetaceae | C-5 β-hydroxylation in platensimycin biosynthesis | |
| MITE0000389 | PaP450-5 | Hydroxylation | Cytochrome P450 | Phomopsis amygdali | Sordariomycetes | hydroxylation of fusicoccin J in the fusicoccin A biosynthetic pathway | |
| MITE0000390 | PaP450-4 | Hydroxylation | Cytochrome P450 | Phomopsis amygdali | Sordariomycetes | Hydroxylase involved in the fusicoccin biosynthetic pathway. | |
| MITE0000391 | PaP450-3 | Hydroxylation | Cytochrome P450 | Phomopsis amygdali | Sordariomycetes | C-9 hydroxylation of precursor in the fusicoccin A biosynthetic pathway. | |
| MITE0000392 | PaP450-1 | Hydroxylation | Cytochrome P450 | Phomopsis amygdali | Sordariomycetes | C-16 hydroxylation of precursor in the Fusicoccin A biosynthetic pathway. | |
| MITE0000393 | PaP450-2 | Hydroxylation | Cytochrome P450 | Phomopsis amygdali | Sordariomycetes | C-8 hydroxylation in the fusicoccin A biosynthetic pathway | |
| MITE0000394 | PhomYa | Hydroxylation | Hydroxylase | Diaporthe leptostromiformis | Sordariomycetes | Hydroxylation of the C-beta of the tyrosine moiety. | |
| MITE0000395 | PhomYb | Cyclization|Oxidation | Oxidase | Diaporthe leptostromiformis | Sordariomycetes | Macrocyclisation | |
| MITE0000396 | AtaPT | Prenylation | Aromatic prenyltransferase | Aspergillus terreus | Eurotiomycetes | C-prenylation of acylphloroglucinols | |
| MITE0000397 | PtmO4 | Dehydrogenation | long-chain acyl-CoA dehydrogenase | Streptomyces platensis | Streptomycetaceae | long-chain acyl-CoA dehydrogenase, is responsible for the formation of t... | |
| MITE0000398 | VdoD | Hydroxylation | Cytochrome P450 | Penicillium palitans | Eurotiomycetes | Hydroxylation of alkaloid scaffold in the viridicatol biosynthetic pathway. | |
| MITE0000399 | MonE | Methylation | O-methyltransferase | Streptomyces virginiae | Streptomycetaceae | MonE catalyzes O-methylation of the hydroxy group at C-3 of demethylmonensin | |
| MITE0000400 | MonD | Hydroxylation | Cytochrome P450 | Streptomyces virginiae | Streptomycetaceae | The preferred order of events in monensin biosynthesis is hydroxylation ... |