MITE0000372
MITE0000373
MITE0000374
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Stereoselective formation of a 1H-oxepin ring from a quinazolinone-containing benzodiazepinedione precursor via an arene oxide intermediate.
Tailoring
  • Ring expansion
Database References
Evidence
  • Heterologous expression
  • In vitro assay
  • Knock-out studies
References
Example 1
Metadata
  • Description: Conversion of the quinazolinone precursor to the 1H-oxepin intermediate
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000373
Entry StatusStatus: active
Enzyme NameOpaB2
Enzyme DescriptionCytochrome P450 enzyme (oxepinase)
Database References
Cofactors
  • Organic
    • Heme
    • NADP
  • Inorganic
    • Fe
References
Commentinserts an oxygen atom into the quinazolinone precursor, catalyzing the arene oxide/ring expansion to generate the 1H-oxepin scaffold
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-04-13)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry. Reviewer 1 fixed reaction (was epoxidation)."