MITE0000427
MITE0000428
MITE0000429
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description CtcP catalyzes the regioselective C-7 chlorination of the tetracycline scaffold to produce chlortetracycline. 4-epi-tetracyclin (4R) is a non-substrate.
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
  • Knock-out studies
References
Example 1
Metadata
  • Description: Chlorination of the (4S) tetracycline as last step in the chlortetracyclin biosynthetic pathway.
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000428
Entry StatusStatus: active
Enzyme NameCtcP
Enzyme DescriptionHalogenase
Database References
Cofactors
  • Organic
    • FAD
References
CommentCtcP is a flavin-dependent halogenase involved in the biosynthesis of the antibiotic chlortetracycline.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-06-26)

Contributor(s)
Reviewer(s)
Comment "New entry. Fixed reaction SMARTS and added additional comments."

Auxiliary Enzyme #1

Enzyme Name CtcQ
Description Flavin reductase
Database References