Minimum Information about a Tailoring Enzyme Repository

MITE0000365

MITE0000366

MITE0000367

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Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	Oxidative ring contraction of a 1,2-dione in the ligustrone biosynthethic pathway.
Tailoring	Ring contraction
Database References	No database crosslinks available
Evidence	Heterologous expression Inference from genomic data and chemical structure Knock-out studies
References	doi:10.1021/jacs.5c03802

Example 1

Metadata	Description: Oxidative ring contraction of a anthracene dione intermediate in the formation of lugustrone A. Intermediate: True
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000366
Entry Status	Status: active
Enzyme Name	LigK
Enzyme Description	Cytochrome P450
Database References	NCBI GenPept: YCL08181.1
Cofactors	Organic Heme Inorganic Fe
References	doi:10.1021/jacs.5c03802
Comment	Catalyzes the oxidative ring contraction
Enzyme Visualization (AlphaFold-predicted)	UniProt ID not available - could not render visualization

Version 1 (2026-05-12)

Contributor(s)	Anonymous MITE contributor
Reviewer(s)	0000-0001-6534-6609
Comment	"New entry. Reviewer 1 corrected genpept accession, removed incorrect uniprot ID, corrected the reaction and substrate, improved descriptions."