MITE0000413
MITE0000414
MITE0000415
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Reaction Information

Number of Known Reactions: 5

Reaction 1
reaction SMARTS
Description Hydroxylation of 3-chloro-β-tyrosyl-S-SgcC2
Tailoring
  • Hydroxylation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Hydroxylation of position 5
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Hydroxylation of 3-iodo-β-tyrosyl-S-SgcC2.
Tailoring
  • Hydroxylation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Hydroxylation of position 5
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 3
reaction SMARTS
Description Hydroxylation of 3-bromo-β-tyrosyl-S-SgcC2.
Tailoring
  • Hydroxylation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Hydroxylation of position 5
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 4
reaction SMARTS
Description Hydroxylation of 3-methyl-β-tyrosyl-S-SgcC2.
Tailoring
  • Hydroxylation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Hydroxylation of position 5
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 5
reaction SMARTS
Description Hydroxylation of β-tyrosyl-S-SgcC2.
Tailoring
  • Hydroxylation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Hydroxylation of position 5
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000414
Entry StatusStatus: active
Enzyme NameSgcC
Enzyme DescriptionFADH2-dependent monooxygenases
Database References
Cofactors
  • Organic
    • FAD
    • NAD
References
CommentHydroxylation of aminoacyl-S-carrier (3-chloro-β-tyrosyl-S-SgcC2) in the lidamycin pathway. Stereochemistry could not be depicted due to incompatibility with validation engine. Additional C-3-substituted substrates: iodine, bromine, chlorine, methyl, and non-substituted.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-07-02)

Contributor(s)
Reviewer(s)
Comment "New entry."

Auxiliary Enzyme #1

Enzyme Name SgcE6
Description Flavin reductase
Database References