MITE0000261
MITE0000262
MITE0000263
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Nitrates free-floating L-tryptophan as the first committed step in the thaxtomin biosynthetic pathway.
Tailoring
  • Other
Database References
Evidence
  • Heterologous expression
  • In vitro assay
  • Site-directed mutagenesis
References
Example 1
Metadata
  • Description: Nitrates L-tryptophan exclusively in 4-position. D-tryptophan is not accepted
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000262
Entry StatusStatus: active
Enzyme NameTxtE
Enzyme DescriptionCytochrome P450
Database References
Cofactors
  • Organic
    • FAD
    • Flavin mononucleotide
    • Heme
    • NAD
    • NADP
  • Inorganic
    • FeS
References
CommentCan only modify tryptophan in 4-position. Enzyme shows some substrate promiscuity (L-tryptophan derivatives) but does not accept D-tryptophan.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-03-08)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."