Minimum Information about a Tailoring Enzyme Repository

MITE0000435

MITE0000436

MITE0000437

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Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	BcmF performs dehydrogenation of the isoleucyl side chain to produce the final product bicyclomycin
Tailoring	Dehydrogenation
Database References	No database crosslinks available
Evidence	In vitro assay Knock-out studies
References	doi:10.1038/s41598-019-56747-7

Example 1

Metadata	Description: No description available Intermediate: False
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000436
Entry Status	Status: active
Enzyme Name	BcmF
Enzyme Description	2OG-Fe(II) oxygenase
Database References	UniParc: UPI000C07B921 NCBI GenPept: PPT15945.1 MIBiG: BGC0001468
Cofactors	Organic a-Ketoglutaric acid Inorganic Fe
References	doi:10.1038/s41598-019-56747-7 doi:10.1021/acs.biochem.7b00943
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-06-14)

Contributor(s)	0009-0008-8086-5325
Reviewer(s)	0000-0002-8323-5416
Comment	"New entry. Reviewer 1 added 2-OG and Fe as cofactors."