MITE0000416
MITE0000417
MITE0000418
Modify entry

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description KtzA deprotonates the Cα resulting in an intramolecular attack on the Cγ, eliminating the chlor substituent which forces the collaps into a cyclopropane ring
Tailoring
  • Cyclization
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Cyclization of γ-chloroisoleucine thioester
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000417
Entry StatusStatus: active
Enzyme NameKtzA
Enzyme Descriptionacyl-CoA dehydrogenase flavoprotein
Database References
References
CommentCyclopropanforming enzyme of γ-chloroisoleucine thetered as thioester on the carrierprotein KtzC in the Kutzneride pathway. Stereochemistry could not be depicted due to incompatibility with validation engine.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-06-25)

Contributor(s)
Reviewer(s)
Comment "New entry."