MITE0000246
MITE0000247
MITE0000248
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Reaction Information

Number of Known Reactions: 2

Reaction 1
reaction SMARTS
Description Oxidative cyclisation of the notoamide E oxidase in the notoamide pathway, leading to notoamide C. NotB shows high substrate specificity.
Tailoring
  • Cyclization
  • Monooxygenation
Database References
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Conversion of notoamide E to notoamide C
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Oxidative cyclisation of the notoamide E oxidase in the notoamide pathway, leading to notoamide D. NotB shows high substrate specificity.
Tailoring
  • Cyclization
  • Monooxygenation
Database References
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Conversion of notoamide E to notoamide D
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000247
Entry StatusStatus: active
Enzyme NameNotB
Enzyme DescriptionFAD-dependent monooxygenase
Database References
Cofactors
  • Organic
    • FAD
    • NADP
References
CommentAA sequences in UniProt ID E1ACP7 and GenPept ID ADM34135.1 differ: UniProt sequence is correct.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-01-01)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."

Version 2 (2026-07-05)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Added note to specify reason for diverging AA sequences Uniprot vs GenPept."