Reaction 1

• Reaction SMARTS
• Reaction Information

Copy reaction SMARTS

Description	StrB installs the Lys-to-Trp crosslink through a C-C bond between the Cβ of Lys and the aromatic C7 of Trp
Tailoring	Biaryl bond formation Cyclization
Database References	No database crosslinks available
Evidence	Heterologous expression In vitro assay Knock-out studies Site-directed mutagenesis
References	doi:10.1038/nchem.2237

Example 1

Metadata	Description: The strA product, 30mer precursor peptide is acted upon by StrB to install the Lys-to-Trp crosslink. The cross-linked product is then further processed likely involving StrC and proteases, to give the final 9-mer cyclic streptide. Intermediate: True
Substrate 1	Copy SMILES
Product 1	Copy SMILES