MITE0000401
MITE0000402
MITE0000403
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Reaction Information

Number of Known Reactions: 3

Reaction 1
reaction SMARTS
Description Single chlorination of L-Thr-S-SyrB1 complex using oxygen
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Chemical probe
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: C4-monochlorination of L-threonin
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Single bromination of L-Thr-S-SyrB1 complex using oxygen. It is possible with bromide surplus but chlorination is always more likely.
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Chemical probe
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: C4-monobromination of L-threonin
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 3
reaction SMARTS
Description Double chlorination of L-Thr-S-SyrB1 complex using oxygen. Dichlorination is only possible in vitro
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Chemical probe
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: C4-dichlorination of L-threonin
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000402
Entry StatusStatus: active
Enzyme NameSyrB2
Enzyme DescriptionNonheme halogenase
Database References
Cofactors
  • Organic
    • a-Ketoglutaric acid
  • Inorganic
    • Fe
References
CommentC4-halogenation of a carrierbound-S-L-Threonin (L-Thr-S-SyrB1) in the syringomycin E pathway.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-06-22)

Contributor(s)
Reviewer(s)
Comment "New entry. Reviewer 1 replaced chiral structure with flat ones due to incompatibility with validation engine."