Minimum Information about a Tailoring Enzyme Repository

MITE0000455

MITE0000456

MITE0000457

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Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	Prenylation of polyketide pyrone substrate in the biosynthetic pathway of decalin-containing diterpenoid pyrones
Tailoring	Prenylation
Database References	BRENDA: 2.5.1 Expasy ENZYME: 2.5.1
Evidence	Heterologous expression
References	doi:10.1038/s41467-020-15664-4

Example 1

Metadata	Description: Geranylgeranylation of 4-hydroxy-5,6-dimethylpyran-2-one to yield corresponding prenylated α-pyrone. Intermediate: True
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000456
Entry Status	Status: active
Enzyme Name	DpasC
Enzyme Description	Prenyl transferase
Database References	UniProtKB: P9WEX2
Cofactors	Inorganic Mg
References	doi:10.1038/s41467-020-15664-4
Comment	Geranylgeranyl transferase active on polyketide pyrone substrate.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-05-06)

Contributor(s)	0000-0002-0771-9611
Reviewer(s)	0000-0003-4819-2251
Comment	"New entry. Reviewer 1 replaced enzyme name and Uniprot ID with chracterized enzyme from the same reference, fixed rxn SMARTS, textual additions."