MITE0000414
MITE0000415
MITE0000416
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Reaction Information

Number of Known Reactions: 2

Reaction 1
reaction SMARTS
Description Chlorination of β-tyrosyl-S-SgcC2. Stereochemistry is determined by SgcC1, therefore SgcC3 functions independently of stereochemistry.
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Chlorination in position 3 of carrier-bound L-tyrosine.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description In vitro bromination of β-tyrosyl-S-SgcC2. Stereochemistry is determined by SgcC1, therefore SgcC3 functions independently of stereochemistry.
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Bromination in position 3
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000415
Entry StatusStatus: active
Enzyme NameSgcC3
Enzyme DescriptionFlavin-dependent halogenase
Database References
References
CommentHalogenation of aminoacyl-S-carrier (β-tyrosyl-S-SgcC2) in the lidamycin (antibiotic C-1027) pathway. Non Substrate: 3-hydroxy-β-tyrosyl-S-SgcC2 (L-DOPA). Non substituent: Iodine and fluorine. Stereochemistry could not be depicted due to incompatibility with validation engine.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-07-01)

Contributor(s)
Reviewer(s)
Comment "New entry."

Auxiliary Enzyme #1

Enzyme Name SgcE6
Description Flavin reductase
Database References