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| Description | Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate |
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| Metadata |
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| Substrate 1 |
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| Product 1 |
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| Accession ID | MITE0000340 |
| Entry Status | Status: active |
| Enzyme Name | FlA1 |
| Enzyme Description | Fluorinase |
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| Comment | Fluorinases mediate the conversion of S-adenosyl-l-methionine (SAM) and inorganic fluoride ions into 5′-fluoro-5′-deoxyadenosine (5′-FDA) and l-methionine. This represents the first step in the production of fluorinated metabolites |
| Enzyme Visualization (AlphaFold-predicted) |
Version 1 (2026-04-17)
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