MITE0000340
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate
Tailoring
  • Halogenation
Database References
Evidence
  • Heterologous expression
  • Inference from genomic data and chemical structure
  • In vitro assay
  • Knock-out studies
References
Example 1
Metadata
  • Description: Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000340
Entry StatusStatus: active
Enzyme NameFlA1
Enzyme DescriptionFluorinase
Database References
References
CommentFluorinases mediate the conversion of S-adenosyl-l-methionine (SAM) and inorganic fluoride ions into 5′-fluoro-5′-deoxyadenosine (5′-FDA) and l-methionine. This represents the first step in the production of fluorinated metabolites
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-04-17)

Contributor(s)
Reviewer(s)
Comment "New entry. Reviewer 2 aligned GenPept ID with MIBiG ID."