MITE0000429
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description NascB catalyzes oxidative dimerization of two molecules of cyclo-(l-tryptophan-l-proline), resulting in simultaneous pyrroloindoline ring formation and C3–C5′ carbon–carbon bond formation to produce naseseazine C.
Tailoring
  • Oxidation
  • Other
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: NascB also converts the synthetic cyclo-(l-tryptophan-l-proline) into naseseazine C and has relaxed substrate specificity.
  • Intermediate: False
Substrate 1 substrate SMILES
Substrate 2 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000429
Entry StatusStatus: active
Enzyme NameNascB
Enzyme DescriptionCytochrome P450
Database References
Cofactors
  • Organic
    • Heme
  • Inorganic
    • Fe
References
CommentNascB catalyzes a radical cascade reaction to form intramolecular and intermolecular carbon-carbon bonds with both regio- and stereo-specificity
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-06-26)

Contributor(s)
Reviewer(s)
Comment "New entry."