Minimum Information about a Tailoring Enzyme Repository

MITE0000112

MITE0000113

MITE0000114

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Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	[6+4] cycloaddition; NgnD acts likely similar to a bispericyclase
Tailoring	Cyclization
Database References	No database crosslinks available
Evidence	Knock-out studies
References	doi:10.1021/acschembio.9b01034

Example 1

Metadata	Description: No description available Intermediate: True
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000113
Entry Status	Status: active
Enzyme Name	NgnD
Enzyme Description	Nuclear transport factor 2 family protein
Database References	UniParc: UPI001005A892 NCBI GenPept: AXG22404.1 MIBiG: BGC0002024
References	doi:10.1021/acschembio.9b01034
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)	0009-0001-3436-5302 Anonymous MITE contributor
Reviewer(s)	0000-0003-0443-9902 0000-0002-9747-3423
Comment	"Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS. Reviewer 2 checked entry for correctness, changed enzyme and reaction description"

Version 2 (2025-07-03)

Contributor(s)	Anonymous MITE contributor
Reviewer(s)	0000-0001-6534-6609
Comment	"Replaced retired UniProtKB ID with UniParc ID. Removed spurious auxiliary Enzymes (referenced in MIBiG BGC)."