MITE0000402
MITE0000403
MITE0000404
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Single Chlorination of Hydroxymethylglutaryl through conformational switch driven by α-ketoglutaric acid.
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Single C4-chlorination of hydroxymethylglutaryl.
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000403
Entry StatusStatus: active
Enzyme NameCurA
Enzyme DescriptionNon-heme halogenase
Database References
Cofactors
  • Organic
    • a-Ketoglutaric acid
  • Inorganic
    • Fe
References
CommentSingle chlorination of the early intermediate Hydroxymethylglutaryl (HMG) in the curacin A pathway. HMG is thioesterified to an acyl carrier protein (ACP). Stereochemistry could not be depicted due to incompatibility with validation engine.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-06-18)

Contributor(s)
Reviewer(s)
Comment "New entry. Reviewer 1 updated general comment."