MITE0000435
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description P450 monooxygenase, TrpB is responsible for the atropospecific formation of one carbon-carbon and two carbon-nitrogen bonds
Tailoring
  • Biaryl bond formation
  • Other
Database References No database crosslinks available
Evidence
  • Heterologous expression
References
Example 1
Metadata
  • Description: TrpB installs three crosslinks on the precursor peptide followed by protease activity to generate the highly constrained hexa- and pentapeptide products Tryptorubin A (AWYIWY) and B (WYIWY).
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000435
Entry StatusStatus: active
Enzyme NameTrpB
Enzyme DescriptionCytochrome P450
Database References
Cofactors
  • Organic
    • Heme
  • Inorganic
    • Fe
References
CommentTrpB installs three crosslinks on the precursor peptide, generating highly constrained atropopeptide scaffold
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-06-22)

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Reviewer(s)
Comment "New entry."