MITE0000405
MITE0000406
MITE0000407
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Reaction Information

Number of Known Reactions: 3

Reaction 1
reaction SMARTS
Description Minimal aminoacid sequence necessary for Chloration: ChlA(-7) DFADLTNGIGSQNPWDTAWLWD
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Single chlorination of tryptophan (Pos: 8).
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Minimal aminoacid sequence necessary for Chloration: ChlA(-7) DFADLTNGIGSQNPWDTAWLWD
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Single chlorination of tryptophan (Pos: 12).
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 3
reaction SMARTS
Description Minimal aminoacid sequence necessary for Chloration: ChlA(-7) DFADLTNGIGSQNPWDTAWLWD.
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Iterativ dichlorination of tryptophan (Pos: 8 and 12).
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000406
Entry StatusStatus: active
Enzyme NameChlH
Enzyme DescriptionFlavin-dependent halogenase
Database References
References
CommentHalogenation of ChlA prescurser peptide in the chlorolassin pathway. Dichloration is the most likley outcome. Terminal tryptophan (Pos: 14) is never chorinated.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-06-10)

Contributor(s)
Reviewer(s)
Comment "New entry."

Auxiliary Enzyme #1

Enzyme Name ChlR
Description flavin reductase
Database References