Reaction 1

• Reaction SMARTS
• Reaction Information

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Description	NigE, encoding a S-adenosylmethionine (SAM)-dependent O-methyltransferase, catalyzes O-methylation of the C-11 hydroxy group in the Nigericin biosynthesis
Tailoring	Methylation
Database References	No database crosslinks available
Evidence	Inference from genomic data and chemical structure
References	doi:10.1016/j.chembiol.2007.05.011 doi:10.1016/j.nbt.2025.02.002

Example 1

Metadata	Description: Methylation of the -OH group at the 11th carbon by NigE Nigericin Intermediate: True
Substrate 1	Copy SMILES
Product 1	Copy SMILES