{
    "accession": "MITE0000456",
    "status": "active",
    "comment": "Geranylgeranyl transferase active on polyketide pyrone substrate.",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0000-0002-0771-9611"
            ],
            "reviewers": [
                "0000-0003-4819-2251"
            ],
            "comment": "New entry. Reviewer 1 replaced enzyme name and Uniprot ID with chracterized enzyme from the same reference, fixed rxn SMARTS, textual additions."
        }
    ],
    "enzyme": {
        "name": "DpasC",
        "description": "Prenyl transferase",
        "references": [
            "doi:10.1038/s41467-020-15664-4"
        ],
        "databaseIds": {
            "uniprot": "P9WEX2"
        },
        "cofactors": {
            "inorganic": [
                "Mg"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Prenylation"
            ],
            "description": "Prenylation of polyketide pyrone substrate in the biosynthetic pathway of decalin-containing diterpenoid pyrones",
            "reactionSMARTS": "[#6:1]-[#6:2]1:[#6:9](-[#6:10]):[#6:7](-[#8:8]):[#6:6]:[#6:4](=[#8:5]):[#8:3]:1>>[#6]-[#6](=[#6]-[#6]-[#6]-[#6](=[#6]-[#6]-[#6]-[#6](=[#6]-[#6]-[#6]-[#6](=[#6]-[#6]-[#6:6]1:[#6:4](=[#8:5]):[#8:3]:[#6:2](-[#6:1]):[#6:9](-[#6:10]):[#6:7]:1-[#8:8])-[#6])-[#6])-[#6])-[#6]",
            "reactions": [
                {
                    "substrate": "Cc1oc(=O)cc(O)c1C",
                    "products": [
                        "CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCc1c(O)c(C)c(C)oc1=O"
                    ],
                    "isIntermediate": true,
                    "description": "Geranylgeranylation of 4-hydroxy-5,6-dimethylpyran-2-one to yield corresponding prenylated \u03b1-pyrone."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1038/s41467-020-15664-4"
                ]
            },
            "databaseIds": {
                "ec": "2.5.1"
            }
        }
    ]
}