{
    "accession": "MITE0000113",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0009-0001-3436-5302",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-0443-9902",
                "0000-0002-9747-3423"
            ],
            "comment": "Initial entry. Reviewer fixed reactionSMARTS:reactionSMARTS. Reviewer 2 checked entry for correctness, changed enzyme and reaction description"
        },
        {
            "version": "2",
            "date": "2025-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc ID. Removed spurious auxiliary Enzymes (referenced in MIBiG BGC)."
        }
    ],
    "enzyme": {
        "name": "NgnD",
        "description": "Nuclear transport factor 2 family protein",
        "references": [
            "doi:10.1021/acschembio.9b01034"
        ],
        "databaseIds": {
            "uniprot": "UPI001005A892",
            "genpept": "AXG22404.1",
            "mibig": "BGC0002024"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization"
            ],
            "description": "[6+4] cycloaddition; NgnD acts likely similar to a bispericyclase",
            "reactionSMARTS": "[#6:1]-[#6:2]-[#6@H:3]1-[#8:4]-[#6:5](=[O:6])-[#6:7]-[#6:8]\\[#6:9]=[#6:10]\\[#6:11]=[#6:12]\\[#6:13]-[#6@H:14](-[#8:15])-[#6@H:16](-[#6:17])-[#6@@H:18](-[#8:19])\\[#6:20]=[#6:21]\\[#6:22](\\[#6:23])=[#6:24]\\[#6@H:25]-1-[#6:26]>>[#6:1]-[#6:2]-[#6@H:3]1-[#8:4]-[#6:5](=[O:6])-[#6:7]-[#6:8]-[#6:9]-2-[#6:10]=[#6:11]-[#6:12]-3-[#6:13]-[#6@H:14](-[#8:15])-[#6@H:16](-[#6:17])-[#6@H:18](-[#8:19])-[#6:20]-3-[#6:21]-2\\[#6:22](-[#6:23])=[#6:24]\\[#6@H:25]-1-[#6:26]",
            "reactions": [
                {
                    "substrate": "CC[C@H]1OC(=O)CC/C=C/C=C/C[C@H](O)[C@H](C)[C@@H](O)/C=C/C(C)=C/[C@H]1C",
                    "products": [
                        "CC[C@H]1OC(=O)CCC2C=CC3C[C@H](O)[C@H](C)[C@H](O)C3C2/C(C)=C/[C@H]1C"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/acschembio.9b01034"
                ]
            }
        }
    ]
}