{
    "accession": "MITE0000467",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0000-0002-9094-8908"
            ],
            "reviewers": [
                "0000-0002-4540-6501"
            ],
            "comment": "New entry. Reviewer 1 changed Description"
        }
    ],
    "enzyme": {
        "name": "atr2",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1128/mBio.01111-21"
        ],
        "databaseIds": {
            "uniprot": "A0A8F4SN83",
            "genpept": "QXF68952.1"
        },
        "cofactors": {
            "organic": [
                "Heme",
                "NADP"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "benzylic hydroxylation of 4-O-demethylbarbatic acid (or proatranorin I) to proatranorin II (or atranorin) ",
            "reactionSMARTS": "[#6:1]-[#6:2]1:[#6:7](-[#6:8](-[#8:10]-[#6:11]2:[#6:16]:[#6:15](-[#6:17]):[#6:14](-[#6:18](-[#8:20])=[#8:19]):[#6:13](-[#8:21]):[#6:12]:2-[#6:22])=[#8:9]):[#6:6](-[#8:23]):[#6:5](-[#6:24]):[#6:4](-[#8:25]):[#6:3]:1>>[#6:1]-[#6:2]1:[#6:7](-[#6:8](-[#8:10]-[#6:11]2:[#6:16]:[#6:15](-[#6:17]):[#6:14](-[#6:18](-[#8:20])=[#8:19]):[#6:13](-[#8:21]):[#6:12]:2-[#6:22])=[#8:9]):[#6:6](-[#8:23]):[#6:5](-[#6:24]-[#8]):[#6:4](-[#8:25]):[#6:3]:1",
            "reactions": [
                {
                    "substrate": "Cc1cc(O)c(C)c(O)c1C(=O)Oc1cc(C)c(C(=O)O)c(O)c1C",
                    "products": [
                        "Cc1cc(OC(=O)c2c(C)cc(O)c(CO)c2O)c(C)c(O)c1C(=O)O"
                    ],
                    "isIntermediate": false,
                    "description": "benzylic hydroxylation"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1128/mbio.01111-21"
                ]
            }
        }
    ]
}