{
    "accession": "MITE0000465",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0000-0001-6660-2715"
            ],
            "reviewers": [
                "0000-0003-3290-1017"
            ],
            "comment": "New entry. Reviewer 1 revised of the product structure."
        }
    ],
    "enzyme": {
        "name": "MrqO5",
        "description": "cofactor-independent monooxygenase",
        "references": [
            "doi:10.1021/acschembio.5c00695"
        ],
        "databaseIds": {
            "uniprot": "A0A1S6QMP3",
            "genpept": "AQW35073.1",
            "mibig": "BGC0001675"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Decarboxylation"
            ],
            "description": "Decarboxylation of aromatic type II polyketide biosynthesis intermediate",
            "reactionSMARTS": "[cH:1]1[cH:3][c:2]2[c:4]([cH:9][c:10]3[c:8]([cH:7]2)[cH:11][c:12]([CH2:15][C:16](=O)O)[c:14]([C:19]([CH2:20][C:21]([CH3:22])=[O:24])=[O:23])[cH:13]3)[cH:6][cH:5]1>>[cH:1]1[cH:3][c:2]2[c:4]([cH:9][c:10]3[c:8]([cH:7]2)[cH:11][c:12]([CH3:15])[c:14]([C:19]([CH2:20][C:21]([CH3:22])=[O:24])=[O:23])[cH:13]3)[cH:6][cH:5]1",
            "reactions": [
                {
                    "substrate": "CC(=O)CC(=O)c1cc2cc3ccccc3cc2cc1CC(=O)O",
                    "products": [
                        "CC(=O)CC(=O)c1cc2cc3ccccc3cc2cc1C"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/acschembio.5c00695"
                ]
            }
        }
    ]
}