{
    "accession": "MITE0000457",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0000-0001-6660-2715"
            ],
            "reviewers": [
                "0009-0008-3623-3734"
            ],
            "comment": "New entry. Reviewer 1 corrected \u2013CH\u2082CH\u2083 to \u2013CH\u2082OH, specified aromatic hydroxylation, and updated the SMILES accordingly."
        }
    ],
    "enzyme": {
        "name": "FogE",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1021/acs.orglett.0c00440"
        ],
        "databaseIds": {
            "uniprot": "A0A017SFB8",
            "genpept": "EYE95339.1",
            "mibig": "BGC0002234"
        },
        "cofactors": {
            "organic": [
                "Heme"
            ],
            "inorganic": [
                "Fe"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "aromatic hydroxylation of flavoglaucin biosynthetic intermediate",
            "reactionSMARTS": "[#6:1]1(-[#8:7]):[#6:5]:[#6:6]:[#6:4]:[#6:2](-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16]):[#6:3]:1-[#6:8]-[#8:9]>>[#6:1]1(-[#8:7]):[#6:5]:[#6:6]:[#6:4](-[#8]):[#6:2](-[#6:10]-[#6:11]-[#6:12]-[#6:13]-[#6:14]-[#6:15]-[#6:16]):[#6:3]:1-[#6:8]-[#8:9]",
            "reactions": [
                {
                    "substrate": "CCCCCCCc1cccc(O)c1CO",
                    "products": [
                        "CCCCCCCc1c(O)ccc(O)c1CO"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.0c00440"
                ]
            }
        }
    ]
}