{
    "accession": "MITE0000443",
    "status": "active",
    "comment": "Catalyzes reverse prenylation of nanangelenin B to produce nanangelenin C.",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-29",
            "contributors": [
                "0000-0001-9260-4650"
            ],
            "reviewers": [
                "0000-0002-4540-6501"
            ],
            "comment": "New entry. Reviewer 1 changed description"
        }
    ],
    "enzyme": {
        "name": "NanD",
        "description": "Prenyltransferase",
        "references": [
            "doi:10.1021/jacs.0c01605"
        ],
        "databaseIds": {
            "uniprot": "A0A6G9KJL7",
            "genpept": "QIQ51364.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Prenylation"
            ],
            "description": "Reverse prenylation of nanangelenin B to produce nanangelenin C.",
            "reactionSMARTS": "[#6:1]12:[#6:23]:[#6:22]:[#6:21]:[#6:20]:[#6:19]:1-[#6:17](=[#8:18])-[#6:16]-[#6@:5](-[#7:6]-[#6:7](-[#6:9]1:[#6:14](-[#7:15]):[#6:13]:[#6:12]:[#6:11]:[#6:10]:1)=[#8:8])-[#6:3](=[#8:4])-[#7:2]-2>>[#6:1]12:[#6:23]:[#6:22]:[#6:21]:[#6:20]:[#6:19]:1-[#6:17](=[#8:18])-[#6:16]-[#6@:5](-[#7:6]-[#6:7](-[#6:9]1:[#6:14](-[#7:15]-[#6](-[#6])(-[#6]=[#6])-[#6]):[#6:13]:[#6:12]:[#6:11]:[#6:10]:1)=[#8:8])-[#6:3](=[#8:4])-[#7:2]-2",
            "reactions": [
                {
                    "substrate": "Nc1ccccc1C(=O)N[C@H]1CC(=O)c2ccccc2NC1=O",
                    "products": [
                        "C=CC(C)(C)Nc1ccccc1C(=O)N[C@H]1CC(=O)c2ccccc2NC1=O"
                    ],
                    "isIntermediate": true,
                    "description": "Reverse prenylation of nanangelenin B to produce nanangelenin C."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/jacs.0c01605"
                ]
            }
        }
    ]
}