{
    "accession": "MITE0000398",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0000-0001-6660-2715"
            ],
            "reviewers": [
                "0000-0003-4819-2251"
            ],
            "comment": "New entry. REviewer 1 added minor textual additions, added cofactor information."
        }
    ],
    "enzyme": {
        "name": "VdoD",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1021/acs.orglett.1c03932"
        ],
        "databaseIds": {
            "genpept": "UHY14094.1"
        },
        "cofactors": {
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "Hydroxylation of alkaloid scaffold in the viridicatol biosynthetic pathway.",
            "reactionSMARTS": "[#6:1]1:[#6:5]:[#6:6]:[#6:4]2-[#7:10]-[#6:11](=[#8:20])-[#6:9]3(-[#8:21]-[#6:12]-3-[#6:13]3:[#6:17]:[#6:18]:[#6:16]:[#6:14]:[#6:15]:3)-[#7:8](-[#6:22])-[#6:7](=[#8:19])-[#6:2]:2:[#6:3]:1>>[#6:1]1:[#6:5]:[#6:6]:[#6:4]2-[#7:10]-[#6:11](=[#8:20])-[#6:9]3(-[#8:21]-[#6:12]-3-[#6:13]3:[#6:17]:[#6:18](-[#8]):[#6:16]:[#6:14]:[#6:15]:3)-[#7:8](-[#6:22])-[#6:7](=[#8:19])-[#6:2]:2:[#6:3]:1",
            "reactions": [
                {
                    "substrate": "CN1C(=O)c2ccccc2NC(=O)C12OC2c1ccccc1",
                    "products": [
                        "CN1C(=O)c2ccccc2NC(=O)C12OC2c1cccc(O)c1"
                    ],
                    "isIntermediate": true,
                    "description": "meta hydroxylation of monoalkylated benzene ring of cyclopenin, to yield cyclopenol."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.1c03932"
                ]
            }
        }
    ]
}