{
    "accession": "MITE0000395",
    "status": "active",
    "comment": "UstYa family oxidase",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0009-0008-4645-6771"
            ],
            "reviewers": [
                "0000-0001-5863-7248"
            ],
            "comment": "New entry."
        }
    ],
    "enzyme": {
        "name": "PhomYb",
        "description": "Oxidase",
        "references": [
            "doi:10.1002/anie.202111076"
        ],
        "databaseIds": {
            "uniprot": "A0A142I729",
            "genpept": "BDA39141.1",
            "mibig": "BGC0001398"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization",
                "Oxidation"
            ],
            "description": "Macrocyclisation",
            "reactionSMARTS": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O>>C=C(C)[C@@H]1NC(=O)[C@@H](N)Cc2cc(Cl)c(O)c(c2)O[C@](C)(CC)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)CC)NC1=O",
            "reactions": [
                {
                    "substrate": "CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1cc(O)c(O)c(Cl)c1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)O",
                    "products": [
                        "C=C(C)[C@@H]1NC(=O)[C@@H](N)Cc2cc(Cl)c(O)c(c2)O[C@](C)(CC)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)CC)NC1=O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1002/anie.202111076"
                ]
            }
        }
    ]
}