{
    "accession": "MITE0000393",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0009-0008-4645-6771"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 replaced reaction SMILES with reaction SMARTS, added GenPept ID, improved descriptions."
        }
    ],
    "enzyme": {
        "name": "PaP450-2",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1371/journal.pone.0042090"
        ],
        "databaseIds": {
            "uniprot": "L0N063",
            "genpept": "BAM71030.1"
        },
        "cofactors": {
            "organic": [
                "Heme"
            ],
            "inorganic": [
                "Fe"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "C-8 hydroxylation in the fusicoccin A biosynthetic pathway",
            "reactionSMARTS": "[#6:1]-[#6:2]1-[#6:20]-[#6:19]\\[#6@:18]2-[#6:3]=1-[#6:4]-[#6@:5]1(-[#6:13](-[#6:14]-[#6:15]-[#6@:16]-2\\[#6:17])=[#6:9](-[#6:10](-[#6:12])-[#6:11])-[#6:8]-[#6:7]-1)\\[#6:6]>>[#6:1]-[#6:2]1-[#6:20]-[#6:19]\\[#6@:18]2-[#6:3]=1-[#6:4]-[#6@:5]1(-[#6:13](-[#6:14]-[#6@@:15](\\[#8])-[#6@:16]-2\\[#6:17])=[#6:9](-[#6:10](-[#6:12])-[#6:11])-[#6:8]-[#6:7]-1)\\[#6:6]",
            "reactions": [
                {
                    "substrate": "CC1=C2C[C@]3(C)CCC(C(C)C)=C3CC[C@@H](C)[C@H]2CC1",
                    "products": [
                        "CC1=C2C[C@]3(C)CCC(C(C)C)=C3C[C@@H](O)[C@@H](C)[C@H]2CC1"
                    ],
                    "isIntermediate": true,
                    "description": "Conversion of fusicocca-2,10(14)-diene to fusicocca-2,10(14)-diene-8b-ol"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1371/journal.pone.0042090"
                ]
            }
        }
    ]
}