{
    "accession": "MITE0000391",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0000-0002-0771-9611"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 replaced reaction SMILES with reaction SMARTS, added genpept and uniprot ID, improved descriptions."
        }
    ],
    "enzyme": {
        "name": "PaP450-3",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1371/journal.pone.0042090"
        ],
        "databaseIds": {
            "uniprot": "L0MYS5",
            "genpept": "BAM71032.1"
        },
        "cofactors": {
            "organic": [
                "Heme"
            ],
            "inorganic": [
                "Fe"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "C-9 hydroxylation of precursor in the fusicoccin A biosynthetic pathway.",
            "reactionSMARTS": "[#6:1](\\[#6@@:2]1-[#6:20]-[#6:19]\\[#6@:18]2-[#6:3]-1=[#6:4]-[#6@:5]1(-[#6:13](-[#6:14]-[#6@@:15](\\[#8:21])-[#6@:16]-2\\[#6:17])=[#6:9](-[#6:10](-[#6:12])-[#6:11])-[#6:8]-[#6:7]-1)\\[#6:6])-[#8:22]>>[#6:1](\\[#6@@:2]1-[#6:20]-[#6:19]\\[#6@:18]2-[#6:3]-1=[#6:4]-[#6@:5]1(-[#6:13](-[#6@:14](/[#8])-[#6@@:15](\\[#8:21])-[#6@:16]-2\\[#6:17])=[#6:9](-[#6:10](-[#6:12])-[#6:11])-[#6:8]-[#6:7]-1)\\[#6:6])-[#8:22]",
            "reactions": [
                {
                    "substrate": "CC(C)C1=C2C[C@@H](O)[C@@H](C)[C@H]3CC[C@@H](CO)C3=C[C@]2(C)CC1",
                    "products": [
                        "CC(C)C1=C2[C@H](O)[C@@H](O)[C@@H](C)[C@H]3CC[C@@H](CO)C3=C[C@]2(C)CC1"
                    ],
                    "isIntermediate": true,
                    "description": "Conversion of fusicocca-1,10(14)-diene-8b,16-diol to fusicoccin H aglycon."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1371/journal.pone.0042090"
                ]
            }
        }
    ]
}