{
    "accession": "MITE0000370",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0009-0006-4188-3294"
            ],
            "reviewers": [
                "0000-0001-9078-9292"
            ],
            "comment": "New entry."
        }
    ],
    "enzyme": {
        "name": "PatE",
        "description": "Patulin synthase",
        "references": [
            "doi:10.1111/1462-2920.14542"
        ],
        "databaseIds": {
            "uniprot": "A0A075TRK9",
            "genpept": "AIG62134.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization"
            ],
            "description": "Conversion of E-ascladiol to patulin",
            "reactionSMARTS": "[#8]-[#6]\\[#6]=[#6]-1\\[#8]-[#6](=O)-[#6]=[#6]-1-[#6]-[#8]>>[#8]-[#6]-1-[#8]-[#6]-[#6]=[#6]-2-[#8]-[#6](=O)-[#6]=[#6]-1-2",
            "reactions": [
                {
                    "substrate": "O=C1C=C(CO)/C(=C\\CO)O1",
                    "products": [
                        "O=C1C=C2C(=CCOC2O)O1"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1111/1462-2920.14542"
                ]
            }
        }
    ]
}