{
    "accession": "MITE0000360",
    "status": "active",
    "comment": "Andilesin B originates from the spontaneous elimination of acetate from Acetylandilesin A (produced by AndG). AndH reduces Andilesin B to produce Andilesin C.",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-17",
            "contributors": [
                "0000-0002-0771-9611"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 improved reaction descriptions."
        }
    ],
    "enzyme": {
        "name": "AndH",
        "description": "Short-chain dehydrogenase/reductase",
        "references": [
            "doi:10.1021/ja508127q"
        ],
        "databaseIds": {
            "uniprot": "A0A097ZPD4",
            "genpept": "BAP81862.1",
            "mibig": "BGC0002612"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Reduction"
            ],
            "description": "Reduction of meroterpenoid intermediate andilesin B in the andilesin biosynthetic pathway.",
            "reactionSMARTS": "[#6@@]123/[#6]/[#6@@]4(-[#6])-[#6]=[#6@]5\\[#6](=[#8])-[#8]-[#6]\\[#6@@]-1-5-[#6@](\\[#6])(-[#6]-4=[#8])-[#6]-[#6]-2-[#6@]1(/[#6])-[#6](-[#6@@](-[#8]-[#6](=[#8])-[#6]=[#6]-1)(\\[#6])/[#6])-[#6]-[#6]-3>>[#6@@]123/[#6]/[#6@@]4(-[#6])-[#6]-[#6@@]5\\[#6](=[#8])-[#8]-[#6]\\[#6@@]-1-5-[#6@](\\[#6])(-[#6]-4=[#8])-[#6]-[#6]-2-[#6@]1(/[#6])-[#6](-[#6@@](-[#8]-[#6](=[#8])-[#6]=[#6]-1)(\\[#6])/[#6])-[#6]-[#6]-3",
            "reactions": [
                {
                    "substrate": "CC1(C)OC(=O)C=C[C@@]2(C)C1CC[C@@]13C[C@@]4(C)C=C5C(=O)OC[C@]51[C@@](C)(CC23)C4=O",
                    "products": [
                        "CC1(C)OC(=O)C=C[C@@]2(C)C1CC[C@@]13C[C@@]4(C)C[C@H]5C(=O)OC[C@]51[C@@](C)(CC23)C4=O"
                    ],
                    "isIntermediate": true,
                    "description": "Conversion of andilesin B to andilesin C."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/ja508127q"
                ]
            }
        }
    ]
}