{
    "accession": "MITE0000352",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-16",
            "contributors": [
                "0000-0002-0771-9611"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 improved reaction descriptions."
        }
    ],
    "enzyme": {
        "name": "AndD",
        "description": "Prenyltransferase",
        "references": [
            "doi:10.1021/ja508127q"
        ],
        "databaseIds": {
            "uniprot": "A0A097ZPE3",
            "genpept": "BAP81858.1",
            "mibig": "BGC0002612"
        },
        "cofactors": {
            "inorganic": [
                "Mg"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Prenylation"
            ],
            "description": "Prenylation as the third step in the anditomin biosynthetic pathway.",
            "reactionSMARTS": "[#6]12-[#6](-[#8]-[#6]-[#6]:1:[#6](-[#6]):[#6](-[#8]):[#6](-[#6]):[#6]:2-[#8])=[#8]>>[#6]12-[#6](-[#8]-[#6]-[#6]=1-[#6@](/[#6]-[#6]=[#6](-[#6]-[#6]-[#6]=[#6](-[#6]-[#6]-[#6]=[#6](-[#6])-[#6])-[#6])-[#6])(\\[#6])-[#6](=[#8])-[#6](-[#6])=[#6]-2-[#8])=[#8]",
            "reactions": [
                {
                    "substrate": "Cc1c(O)c(C)c2c(c1O)C(=O)OC2",
                    "products": [
                        "CC(C)=CCCC(C)=CCCC(C)=CC[C@@]1(C)C(=O)C(C)=C(O)C2=C1COC2=O"
                    ],
                    "isIntermediate": true,
                    "description": "Prenylation of 5,7-dihydroxy-4,6-dimethylphtalide (DHDMP) to generate farnesyl-DHDMP."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/ja508127q"
                ]
            }
        }
    ]
}