{
    "accession": "MITE0000350",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-06",
            "contributors": [
                "0009-0000-8651-1669"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 expanded descriptions, fixed substrate specificity, and fixed DOIs."
        }
    ],
    "enzyme": {
        "name": "Ulm24",
        "description": "Flavin-dependent halogenase",
        "references": [
            "doi:10.1021/acs.jnatprod.7b00660"
        ],
        "auxiliaryEnzymes": [
            {
                "name": "Ulm26",
                "description": "Flavin reductase",
                "databaseIds": {
                    "uniprot": "A0A2D3E324",
                    "genpept": "ATU31803.1"
                }
            }
        ],
        "databaseIds": {
            "uniprot": "A0A2D3E318",
            "genpept": "ATU31801.1",
            "mibig": "BGC0001814"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "5-halogenation of L-tryptophan in the ulleungmycin pathway. Exact occurrence of halogenation in the pathway currently undefined.",
            "reactionSMARTS": "[#7:1]\\[#6@:2](-[#6:13]=[#8:14])-[#6:3]-[#6:4]1:[#6:8]2:[#6:9]:[#6:10]:[#6:11]:[#6:12]:[#6:7]:2:[#7:6]:[#6:5]:1>>[#7:1]\\[#6@:2](-[#6:13]=[#8:14])-[#6:3]-[#6:4]1:[#6:8]2:[#6:9]:[#6:10](-[Cl]):[#6:11]:[#6:12]:[#6:7]:2:[#7:6]:[#6:5]:1",
            "reactions": [
                {
                    "substrate": "N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O",
                    "products": [
                        "N[C@@H](Cc1c[nH]c2ccc(Cl)cc12)C(=O)O"
                    ],
                    "isIntermediate": false,
                    "description": "Halogenation of free-floating tryptophan as precursor used in the ulleungmycin pathway."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.1021/acs.jnatprod.7b00660"
                ]
            }
        }
    ]
}