{
    "accession": "MITE0000348",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-05-03",
            "contributors": [
                "0000-0001-9487-1525"
            ],
            "reviewers": [
                "0000-0002-9747-3423",
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 2 removed MIBiG BGC cross-reference (was BGC0000924) since it describes the gene cluster from Pseudomonas chlororaphis, while the paper describes the one from Pseudomonas fluorescens."
        }
    ],
    "enzyme": {
        "name": "PrnC",
        "description": "Flavin-dependent halogenase",
        "references": [
            "doi:10.1038/s42004-023-01083-1",
            "doi:10.1002/1615-4169(200108)343:6/7%3C591::AID-ADSC591%3E3.0.CO;2-E"
        ],
        "databaseIds": {
            "uniprot": "P95482",
            "genpept": "AAB97506.1"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "Site-specific chlorination of pyrrolic heterocycles.",
            "reactionSMARTS": "[#6:1]1(:[#6:10]:[#6:11]:[#6:9]:[#6:7](-[Cl:13]):[#6:8]:1-[#7:12])-[#6:2]1:[#6:4]:[#6:3]:[#7:5]:[#6:6]:1>>[#6:1]1(:[#6:10]:[#6:11]:[#6:9]:[#6:7](-[Cl:13]):[#6:8]:1-[#7:12])-[#6:2]1:[#6:4](-[Cl]):[#6:3]:[#7:5]:[#6:6]:1",
            "reactions": [
                {
                    "substrate": "Nc1c(Cl)cccc1-c1cc[nH]c1",
                    "products": [
                        "Nc1c(Cl)cccc1-c1c[nH]cc1Cl"
                    ],
                    "isIntermediate": true,
                    "description": "Chlorination of monodechloroaminopyrrolnitrin to form aminopyrrolnitrin."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1038/s42004-023-01083-1"
                ]
            }
        }
    ]
}