{
    "accession": "MITE0000345",
    "status": "active",
    "comment": "dimethylallyl tryptophan synthase (DMATS)-type PT",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-26",
            "contributors": [
                "0000-0002-8834-593X"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "New entry."
        }
    ],
    "enzyme": {
        "name": "AuraA",
        "description": "Prenyltransferase",
        "references": [
            "doi:10.1038/s41467-024-55537-8"
        ],
        "databaseIds": {
            "uniprot": "UPI0039BD93EE",
            "genpept": "XJW06602.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "description": "C-prenylation on the imidazole moiety of dihydroviridamine (imidazole-C-dimethylallyl products)",
            "reactionSMARTS": "[#6:1]-[#6:2](-[#6:4]1-[#6:16](=[#8:17])-[#7:15]-[#6:8](-[#6:9]-[#6:10]2:[#7:14]:[#6:13]:[#7:12]:[#6:11]:2)-[#6:6](=[#8:7])-[#7:5]-1)-[#6:3]>>[#6]-[#6](=[#6]-[#6]-[#6:13]1:[#7:12]:[#6:11]:[#6:10](-[#6:9]-[#6:8]2-[#6:6](=[#8:7])-[#7:5]-[#6:4](-[#6:2](-[#6:1])-[#6:3])-[#6:16](=[#8:17])-[#7:15]-2):[#7:14]:1)-[#6]",
            "reactions": [
                {
                    "substrate": "CC(C)C1NC(=O)C(Cc2c[nH]cn2)NC1=O",
                    "products": [
                        "CC(C)=CCc1nc(CC2NC(=O)C(C(C)C)NC2=O)c[nH]1"
                    ],
                    "isIntermediate": true,
                    "description": "C-prenylation on the imidazole moiety of dihydroviridamine (imidazole-C-dimethylallyl products)"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1038/s41467-024-55537-8"
                ]
            }
        }
    ]
}