{
    "accession": "MITE0000343",
    "status": "active",
    "comment": "Hydroxylation of thiocarboxylic acid into sulfenic acid",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-20",
            "contributors": [
                "0000-0002-3947-4444"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Add new entry for Taah flavin-dependent S-hydroxylase"
        }
    ],
    "enzyme": {
        "name": "TaaH",
        "description": "Flavin-dependent S-hydroxylase",
        "references": [
            "doi:10.1038/s41557-025-01833-9"
        ],
        "databaseIds": {
            "uniprot": "UPI00041FAA4D"
        },
        "cofactors": {
            "organic": [
                "FAD",
                "NAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "Hydroxylation of thiocarboxylic acid into sulfenic acid",
            "reactionSMARTS": "[#16:1]1:[#6:3](-[#6@@:9](-[#6@@:11](/[#8:13])-[#6@:12](-[#6:15]-[#6@@:16](\\[#6:18])-[#6:17]-[#6:19]-[#6:20])\\[#6:14])/[#6:10]):[#7:2]:[#6:4](-[#6:6](-[#16:8])=[#8:7]):[#6:5]:1>>[#16:1]1:[#6:3](-[#6@@:9](-[#6@@:11](/[#8:13])-[#6@:12](-[#6:15]-[#6@@:16](\\[#6:18])-[#6:17]-[#6:19]-[#6:20])\\[#6:14])/[#6:10]):[#7:2]:[#6:4](-[#6:6](-[#16:8]-[#8])=[#8:7]):[#6:5]:1",
            "reactions": [
                {
                    "substrate": "CCC[C@H](C)C[C@H](C)[C@H](O)[C@@H](C)c1nc(C(=O)S)cs1",
                    "products": [
                        "CCC[C@H](C)C[C@H](C)[C@H](O)[C@@H](C)c1nc(C(=O)SO)cs1"
                    ],
                    "isIntermediate": true,
                    "description": "Hydroxylation of thiocarboxylic acid into sulfenic acid"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1038/s41557-025-01833-9"
                ]
            },
            "databaseIds": {
                "ec": "1.14.13"
            }
        }
    ]
}