{
    "accession": "MITE0000335",
    "status": "active",
    "comment": "Cytochrome P450 monooxygenase; M-cresol hydroxylase",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-14",
            "contributors": [
                "0000-0001-5730-3326"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "New entry."
        }
    ],
    "enzyme": {
        "name": "PatH",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1111/1462-2920.14542"
        ],
        "databaseIds": {
            "uniprot": "A0A075TRL5",
            "genpept": "AIG62144.1",
            "mibig": "BGC0000120"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "Hydroxylation of m-cresol in patulin biosynthetic pathway.",
            "reactionSMARTS": "[#8:1]-[#6:2]1:[#6:8]:[#6:7]:[#6:6]:[#6:4](-[#6:5]):[#6:3]:1>>[#8:1]-[#6:2]1:[#6:8]:[#6:7]:[#6:6]:[#6:4](-[#6:5]-[#8]):[#6:3]:1",
            "reactions": [
                {
                    "substrate": "Cc1cccc(O)c1",
                    "products": [
                        "OCc1cccc(O)c1"
                    ],
                    "isIntermediate": true,
                    "description": "Hydroxylation of m-cresol in patulin biosynthetic pathway."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1111/1462-2920.14542"
                ]
            }
        }
    ]
}