{
    "accession": "MITE0000323",
    "status": "retired",
    "comment": "standalone ArCP\u2013TE  didomain protein (standalone ArCP\u2013TE  didomain protein, acting trans).",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-15",
            "contributors": [
                "0000-0003-2163-5526"
            ],
            "reviewers": [
                "0000-0002-9747-3423",
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 2 fixed reaction SMARTS to show full substrate specificity, retired entry due to not being a tailoring enzyme."
        }
    ],
    "enzyme": {
        "name": "KinT",
        "description": "Thioesterase",
        "references": [
            "doi:10.64898/2026.02.23.707395"
        ],
        "databaseIds": {
            "genpept": "MHN9097960.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization"
            ],
            "description": "Intramolecular  cyclization of hydroxy-ornithine in kineochelin siderophore",
            "reactionSMARTS": "[#6@:1]1(/[#6:2](-[#7:4]-[#6:5]-[#6:6](-[#7:8]\\[#6@:9](-[#6:17](-[#7:19]\\[#6@@:20](-[#6:23](-[#7:25]/[#6@@:26](-[#6:29](-[#7:31]/[#6@:32](-[#6:38](-[*])=[#8:39])-[#6:33]-[#6:34]-[#6:35]-[#7:36]-[#8:37])=[#8:30])-[#6:27]-[#8:28])=[#8:24])-[#6:21]-[#8:22])=[#8:18])-[#6:10]-[#6:11]-[#6:12]-[#7:13](-[#6:15]=[#8:16])-[#8:14])=[#8:7])=[#8:3])-[#7:42]=[#6:44](-[#6:46]2:[#6:50]:[#6:51]:[#6:49]:[#6:47]:[#6:48]:2-[#8:52])-[#8:43]-[#6@@:41]-1\\[#6:45]>>[#6@:1]1(/[#6:2](-[#7:4]-[#6:5]-[#6:6](-[#7:8]\\[#6@:9](-[#6:17](-[#7:19]\\[#6@@:20](-[#6:23](-[#7:25]/[#6@@:26](-[#6:29](-[#7:31]/[#6@@:32]2-[#6:38](-[#7:36](-[#8:37])-[#6:35]-[#6:34]-[#6:33]-2)=[#8:39])=[#8:30])-[#6:27]-[#8:28])=[#8:24])-[#6:21]-[#8:22])=[#8:18])-[#6:10]-[#6:11]-[#6:12]-[#7:13](-[#6:15]=[#8:16])-[#8:14])=[#8:7])=[#8:3])-[#7:42]=[#6:44](-[#6:46]2:[#6:50]:[#6:51]:[#6:49]:[#6:47]:[#6:48]:2-[#8:52])-[#8:43]-[#6@@:41]-1\\[#6:45]",
            "reactions": [
                {
                    "substrate": "*C(=O)[C](CCCNO)NC(=O)[C](CO)NC(=O)[C](CO)NC(=O)[C](CCCN(O)C=O)NC(=O)CNC(=O)[C@]1N=C(c2ccccc2O)O[C@]1C",
                    "products": [
                        "CC1OC(c2ccccc2O)=NC1C(=O)NCC(=O)NC(CCCN(O)C=O)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC1CCCN(O)C1=O"
                    ],
                    "isIntermediate": true,
                    "description": "Intramolecular cyclization of hydroxy-ornithine in kineochelin siderophore"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.64898/2026.02.23.707395"
                ]
            }
        }
    ]
}