{
    "accession": "MITE0000320",
    "status": "active",
    "comment": "XptC-catalysed oxidation to give the aldehyde in the emodin pathway (see MIBiG entry BGC0000101).",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-13",
            "contributors": [
                "0000-0001-5730-3326"
            ],
            "reviewers": [
                "0000-0002-9747-3423",
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 2 removed MIBiG cross-reference - MIBiG entry does not contain protein reference."
        }
    ],
    "enzyme": {
        "name": "XptC",
        "description": "Oxidoreductase",
        "references": [
            "doi:10.1002/cbic.201200014"
        ],
        "databaseIds": {
            "uniprot": "Q5AUN2",
            "genpept": "CBF73676.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "description": "Oxidation reactions of primary alcohol to an aldehyde.",
            "reactionSMARTS": "[#6:1]-[#6:2](=[#6:4]-[#6:5]-[#8:6]-[#6:7]1:[#6:28](-[#6:29]-[#8]):[#6:27]2:[#6:11](:[#8:12]:[#6:13]3:[#6:24](:[#6:25]:2=[#8:26]):[#6:22](-[#8:23]):[#6:21]:[#6:20]:[#6:14]:3-[#6:15]-[#6:16]=[#6:17](-[#6:19])-[#6:18]):[#6:10]:[#6:8]:1-[#6:9])-[#6:3]>>[#6:1]-[#6:2](=[#6:4]-[#6:5]-[#8:6]-[#6:7]1:[#6:28](-[#6:29]=[#8:6]):[#6:27]2:[#6:11](:[#8:12]:[#6:13]3:[#6:24](:[#6:25]:2=[#8:26]):[#6:22](-[#8:23]):[#6:21]:[#6:20]:[#6:14]:3-[#6:15]-[#6:16]=[#6:17](-[#6:19])-[#6:18]):[#6:10]:[#6:8]:1-[#6:9])-[#6:3]",
            "reactions": [
                {
                    "substrate": "CC(C)=CCOc1c(C)cc2oc3c(CC=C(C)C)ccc(O)c3c(=O)c2c1CO",
                    "products": [
                        "CC(C)=CCOc1c(C)cc2oc3c(CC=C(C)C)ccc(O)c3c(=O)c2c1C=O"
                    ],
                    "isIntermediate": true,
                    "description": "Oxidation reactions of primary alcohol to an aldehyde, the precursor for the cyclization to (cis) epishamixanthone."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1002/cbic.201200014"
                ]
            }
        }
    ]
}