{
    "accession": "MITE0000312",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-13",
            "contributors": [
                "0000-0001-9433-5204"
            ],
            "reviewers": [
                "0000-0002-8323-5416",
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 updated evidence qualifiers. Reviewer 2 added atom mapping."
        }
    ],
    "enzyme": {
        "name": "NocO",
        "description": "Halogenase",
        "references": [
            "doi:10.1021/acs.biochem.4c00720"
        ],
        "databaseIds": {
            "uniprot": "UPI001881292C",
            "genpept": "QOV09192.1"
        },
        "cofactors": {
            "organic": [
                "NADP"
            ],
            "inorganic": [
                "Fe"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Halogenation"
            ],
            "description": "Diiron radical halogenase.",
            "reactionSMARTS": "[#6:1](-[*])(=[#8:13])-[#6:2]-[#6:3]-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]>>[#6:1](-[*])(=[#8:13])-[#6:2]-[#6:3]-[#6:4]-[#6:5]-[#6:6]-[#6:7]-[#6:8]-[#6:9]-[#6:10]-[#6:11]-[#6:12]-Cl",
            "reactions": [
                {
                    "substrate": "*C(=O)CCCCCCCCCCC",
                    "products": [
                        "*C(=O)CCCCCCCCCCCCl"
                    ],
                    "isIntermediate": true,
                    "description": "Chlorination of NocM-tethered dodecanoyl thioester."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/acs.biochem.4c00720"
                ]
            }
        }
    ]
}