{
    "accession": "MITE0000303",
    "status": "active",
    "comment": "GulG is a likely candidate for the hydroxylation in alpha position to the keto group due its sequence homology to macrolide carbon hydroxylases, such as EryK, yielding aglycon of gulmirecin.",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-13",
            "contributors": [
                "0000-0001-5730-3326"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "New entry."
        }
    ],
    "enzyme": {
        "name": "GulG",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1002/chem.201404291"
        ],
        "databaseIds": {
            "uniprot": "A0A097I351",
            "genpept": "AIT55258.1",
            "mibig": "BGC0000072"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "Hydroxylation reaction towards gulmirecin.",
            "reactionSMARTS": "[#6:1]-[#6:2]=[#6:3](-[#6:22])/[#6@@:4]1-[#8:17]-[#6:16](=[#8:18])-[#6@@:15](\\[#6:19])-[#6@:13](/[#8:14])-[#6:12]-[#6:11](=[#8:20])-[#6:10]-[#6@:8](/[#8:9])-[#6:7](-[#6:21])=[#6:6]-[#6:5]-1>>[#6:1]-[#6:2]=[#6:3](/[#6@:4]1-[#6:5]-[#6:6]=[#6:7](-[#6:21])-[#6@@:8](/[#8:9])-[#6@:10](\\[#8])-[#6:11](=[#8:20])-[#6:12]-[#6@@:13](/[#8:14])-[#6@:15](\\[#6:19])-[#6:16](=[#8:18])-[#8:17]-1)-[#6:22]",
            "reactions": [
                {
                    "substrate": "C/C=C(/C)[C@H]1C/C=C(\\C)[C@@H](O)CC(=O)C[C@@H](O)[C@H](C)C(=O)O1",
                    "products": [
                        "CC=C(C)[C@H]1CC=C(C)[C@@H](O)[C@H](O)C(=O)C[C@@H](O)[C@H](C)C(=O)O1"
                    ],
                    "isIntermediate": true,
                    "description": "Hydroxylation reaction yielding aglycon of gulmirecin."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.1002/chem.201404291"
                ]
            }
        }
    ]
}