{
    "accession": "MITE0000292",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-03-25",
            "contributors": [
                "0009-0003-2819-1486"
            ],
            "reviewers": [
                "0000-0001-5863-7248"
            ],
            "comment": "New entry."
        },
        {
            "version": "2",
            "date": "2026-07-11",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Replaced retired UniProtKB ID with UniParc one."
        }
    ],
    "enzyme": {
        "name": "RslO5",
        "description": "FMN-dependent reductase",
        "references": [
            "doi:10.1021/jacs.9b12736"
        ],
        "databaseIds": {
            "uniprot": "UPI00042E4834",
            "genpept": "AHL46723.1"
        },
        "cofactors": {
            "organic": [
                "Flavin mononucleotide"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Reduction"
            ],
            "description": "FMN-dependent reductive epoxide opening of intermediate from the rishirilide biosynthesis pathway.",
            "reactionSMARTS": "[#6:1]1:[#6:5](-[#8:7]):[#6:6]2:[#6:10](-[#8:16]):[#6:11]3-[#6:12](=[#8:17])-[#6:13]4(-[#6:21](-[#6:23]-[#6:24]-[#6:25](-[#6:27])-[#6:26])=[#8:22])-[#8:19]-[#6:14]-4(-[#6:20])-[#6:15](=[#8:18])-[#6:9]:3:[#6:8]:[#6:4]:2:[#6:3]:[#6:2]:1>>[#6:1]1:[#6:5](-[#8:7]):[#6:6]2:[#6:10](-[#8:16]):[#6:11]3-[#6:12](=[#8:17])-[#6:13](-[#6:21](-[#6:23]-[#6:24]-[#6:25](-[#6:27])-[#6:26])=[#8:22])(-[#8:19])-[#6:14](-[#6:20])-[#6:15](=[#8:18])-[#6:9]:3:[#6:8]:[#6:4]:2:[#6:3]:[#6:2]:1",
            "reactions": [
                {
                    "substrate": "CC(C)CCC(=O)C12OC1(C)C(=O)c1cc3cccc(O)c3c(O)c1C2=O",
                    "products": [
                        "CC(C)CCC(=O)C1(O)C(=O)c2c(cc3cccc(O)c3c2O)C(=O)C1C"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/jacs.9b12736"
                ]
            }
        }
    ]
}