{
    "accession": "MITE0000283",
    "status": "active",
    "comment": "Catalyzes the regioselective rearrangement of the 10,11-epoxide into a 2,5-dihydrofuran ring via ring expansion.",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-04",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "New entry."
        }
    ],
    "enzyme": {
        "name": "DovD",
        "description": "Epoxide expandase (Cyclase)",
        "references": [
            "doi:10.1039/D5SC03423J"
        ],
        "databaseIds": {
            "uniprot": "A0A1V6NP10",
            "genpept": "OQD66319.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization",
                "Ring expansion"
            ],
            "description": "Conversion of a 10,11-epoxide polyene intermediate into a tetrahydrofuran (2,5-dihydrofuran) derivative.",
            "reactionSMARTS": "[#6:1]1(-[#6:8]):[#6:2](=[#8:7]):[#8:3]:[#6:4](-[#6:11](=[#6:13]-[#6:14](-[#6:16])=[#6:15]-[#6:17](-[#6:19])=[#6:18]-[#6:20](-[#6:22])=[#6:21]-[#6:23]2(-[#8:27]-[#6:24]-2-[#6])-[#6:25])-[#6:12]):[#6:5](-[#6:10]):[#6:6]:1-[#8:9]>>[#6:1]1(-[#6:8]):[#6:2](=[#8:7]):[#8:3]:[#6:4](-[#6:11](=[#6:13]-[#6:14](-[#6:16])=[#6:15]-[#6:17](-[#6:19])=[#6:18]-[#6:20]2=[#6:21](-[#6:22])-[#6:23](-[#6:25])-[#8:27]-[#6:24]-2)-[#6:12]):[#6:5](-[#6:10]):[#6:6]:1-[#8:9]",
            "reactions": [
                {
                    "substrate": "CC(=CC(C)=CC1(C)OC1C)C=C(C)C=C(C)c1oc(=O)c(C)c(O)c1C",
                    "products": [
                        "CC(=CC(C)=CC1=C(C)C(C)OC1)C=C(C)c1oc(=O)c(C)c(O)c1C"
                    ],
                    "isIntermediate": true,
                    "description": "Transformation of epoxide to intermediate 2,5-dihydrofuran."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1039/D5SC03423J"
                ]
            },
            "databaseIds": {
                "ec": "5.5.1"
            }
        }
    ]
}