{
    "accession": "MITE0000277",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2026-04-07",
            "contributors": [
                "0000-0003-4087-0708"
            ],
            "reviewers": [
                "0000-0002-8323-5416"
            ],
            "comment": "New entry. Reviewer 1 updated description"
        }
    ],
    "enzyme": {
        "name": "LtxC",
        "description": "Prenyltransferase / Geranyl transferase",
        "references": [
            "doi:10.1021/ja047876g"
        ],
        "databaseIds": {
            "uniprot": "Q5V8A6",
            "genpept": "AAT12285.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Prenylation"
            ],
            "description": "Prenyltransferase / Geranyl transferase",
            "reactionSMARTS": "[#6:1]-[#7:2]1-[#6:17]2:[#6:22]:[#6:21]:[#6:20]:[#6:19]3:[#7:13]:[#6:12]:[#6:11](:[#6:18]:2:3)-[#6:10]-[#6:9](-[#6:14]-[#8:15])-[#7:8]-[#6:7](=[#8:16])-[#6:3]-1-[#6:4](-[#6:6])-[#6:5]>>[#6:1]-[#7:2]1-[#6:17]2:[#6:22]:[#6:21]:[#6:20](-[#6](-[#6]=[#6])(-[#6])-[#6]-[#6]-[#6]=[#6](-[#6])-[#6]):[#6:19]3:[#7:13]:[#6:12]:[#6:11](:[#6:18]:2:3)-[#6:10]-[#6:9](-[#6:14]-[#8:15])-[#7:8]-[#6:7](=[#8:16])-[#6:3]-1-[#6:4](-[#6:6])-[#6:5]",
            "reactions": [
                {
                    "substrate": "CC(C)C1C(=O)NC(CO)Cc2c[nH]c3cccc(c23)N1C",
                    "products": [
                        "C=CC(C)(CCC=C(C)C)c1ccc2c3c(c[nH]c13)CC(CO)NC(=O)C(C(C)C)N2C"
                    ],
                    "isIntermediate": false,
                    "description": "catalyze the transfer of a geranyl group to (\u2212)-indolactam V as the final step in the biosynthesis of lyngbyatoxin A"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/ja047876g"
                ]
            }
        }
    ]
}