{
    "accession": "MITE0000268",
    "status": "active",
    "comment": "Transfers variable sugar moieties to antaraglycone.",
    "changelog": [
        {
            "version": "1",
            "date": "2026-03-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 converted reaction SMILES to reaction SMARTS and added reaction descriptions."
        }
    ],
    "enzyme": {
        "name": "AntC",
        "description": "Glycosyltransferase",
        "references": [
            "doi:10.1021/jacsau.4c00912"
        ],
        "databaseIds": {
            "genpept": "WJP00495.1"
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Glycosylation"
            ],
            "description": "Transfer of two vancosamine moieties to the C-13 and C-13' positions of antaraglycone, yielding Antarmycin C.",
            "reactionSMARTS": "[#6:1]-[#6:2]1-[#6:36](-[#6:37](-[#6:39](-[#6:41](-[#6:43]2(-[#8:52]-[#6:50](-[#6:51])-[#6:48](-[#6:49])-[#6:46](-[#8:47])-[#6:45]-2)-[#8:44])-[#6:42])-[#8:40])-[#6:38])-[#8:35]-[#6:33](=[#8:34])-[#6:32]=[#6:31]-[#6:30]=[#6:29]-[#6:27](-[#6:28])-[#6:10](-[#6:11](-[#6:13](-[#6:15](-[#6:17]2(-[#8:26]-[#6:24](-[#6:25])-[#6:22](-[#6:23])-[#6:20](-[#8:21])-[#6:19]-2)-[#8:18])-[#6:16])-[#8:14])-[#6:12])-[#8:9]-[#6:7](=[#8:8])-[#6:6]=[#6:5]-[#6:4]=[#6:3]-1>>[#6:1]-[#6:2]1-[#6:36](-[#6:37](-[#6:39](-[#6:41](-[#6:43]2(-[#8:52]-[#6:50](-[#6:51])-[#6:48](-[#6:49])-[#6:46](-[#8:47]-[#6]3-[#8]-[#6](-[#6])-[#6](-[#6](-[#7])(-[#6])-[#6]-3)-[#8])-[#6:45]-2)-[#8:44])-[#6:42])-[#8:40])-[#6:38])-[#8:35]-[#6:33](=[#8:34])-[#6:32]=[#6:31]-[#6:30]=[#6:29]-[#6:27](-[#6:28])-[#6:10](-[#6:11](-[#6:13](-[#6:15](-[#6:17]2(-[#8:26]-[#6:24](-[#6:25])-[#6:22](-[#6:23])-[#6:20](-[#8:21]-[#6]3-[#6]-[#6](-[#7])(-[#6])-[#6](-[#8])-[#6](-[#6])-[#8]-3)-[#6:19]-2)-[#8:18])-[#6:16])-[#8:14])-[#6:12])-[#8:9]-[#6:7](=[#8:8])-[#6:6]=[#6:5]-[#6:4]=[#6:3]-1",
            "reactions": [
                {
                    "substrate": "CC1/C=C/C=C/C(=O)OC(C(C)C(O)C(C)C2(O)CC(O)C(C)C(C)O2)C(C)/C=C/C=C/C(=O)OC1C(C)C(O)C(C)C1(O)CC(O)C(C)C(C)O1",
                    "products": [
                        "CC1C=CC=CC(=O)OC(C(C)C(O)C(C)C2(O)CC(OC3CC(C)(N)C(O)C(C)O3)C(C)C(C)O2)C(C)C=CC=CC(=O)OC1C(C)C(O)C(C)C1(O)CC(OC2CC(C)(N)C(O)C(C)O2)C(C)C(C)O1"
                    ],
                    "isIntermediate": true,
                    "description": "Conversion of antaraglycone to Antarmycin C."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/jacsau.4c00912"
                ]
            },
            "databaseIds": {
                "ec": "2.4.1"
            }
        },
        {
            "tailoring": [
                "Glycosylation"
            ],
            "description": "Transfer of two rhamnose moieties to the C-13 and C-13' positions of antaraglycone, yielding Antarmycin B. Observed in the delta-antB3 mutant strain.",
            "reactionSMARTS": "[#6:1]-[#6:2]1-[#6:36](-[#6:37](-[#6:39](-[#6:41](-[#6:43]2(-[#8:52]-[#6:50](-[#6:51])-[#6:48](-[#6:49])-[#6:46](-[#8:47])-[#6:45]-2)-[#8:44])-[#6:42])-[#8:40])-[#6:38])-[#8:35]-[#6:33](=[#8:34])-[#6:32]=[#6:31]-[#6:30]=[#6:29]-[#6:27](-[#6:28])-[#6:10](-[#6:11](-[#6:13](-[#6:15](-[#6:17]2(-[#8:26]-[#6:24](-[#6:25])-[#6:22](-[#6:23])-[#6:20](-[#8:21])-[#6:19]-2)-[#8:18])-[#6:16])-[#8:14])-[#6:12])-[#8:9]-[#6:7](=[#8:8])-[#6:6]=[#6:5]-[#6:4]=[#6:3]-1>>[#6:1]-[#6:2]1-[#6:36](-[#6:37](-[#6:39](-[#6:41](-[#6:43]2(-[#8:52]-[#6:50](-[#6:51])-[#6:48](-[#6:49])-[#6:46](-[#8:47]-[#6]3-[#8]-[#6](-[#6])-[#6](-[#6](-[#8])-[#6]-3-[#8])-[#8])-[#6:45]-2)-[#8:44])-[#6:42])-[#8:40])-[#6:38])-[#8:35]-[#6:33](=[#8:34])-[#6:32]=[#6:31]-[#6:30]=[#6:29]-[#6:27](-[#6:28])-[#6:10](-[#6:11](-[#6:13](-[#6:15](-[#6:17]2(-[#8:26]-[#6:24](-[#6:25])-[#6:22](-[#6:23])-[#6:20](-[#8:21]-[#6]3-[#6](-[#8])-[#6](-[#8])-[#6](-[#8])-[#6](-[#6])-[#8]-3)-[#6:19]-2)-[#8:18])-[#6:16])-[#8:14])-[#6:12])-[#8:9]-[#6:7](=[#8:8])-[#6:6]=[#6:5]-[#6:4]=[#6:3]-1",
            "reactions": [
                {
                    "substrate": "CC1/C=C/C=C/C(=O)OC(C(C)C(O)C(C)C2(O)CC(O)C(C)C(C)O2)C(C)/C=C/C=C/C(=O)OC1C(C)C(O)C(C)C1(O)CC(O)C(C)C(C)O1",
                    "products": [
                        "CC1C=CC=CC(=O)OC(C(C)C(O)C(C)C2(O)CC(OC3OC(C)C(O)C(O)C3O)C(C)C(C)O2)C(C)C=CC=CC(=O)OC1C(C)C(O)C(C)C1(O)CC(OC2OC(C)C(O)C(O)C2O)C(C)C(C)O1"
                    ],
                    "isIntermediate": true,
                    "description": "Conversion of antaraglycone to Antarmycin B."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1021/jacsau.4c00912"
                ]
            },
            "databaseIds": {
                "ec": "2.4.1"
            }
        }
    ]
}