{
    "accession": "MITE0000206",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2025-03-27",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0003-4819-2251",
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 refined reaction SMARTS specificity. Reviewer 2 added stereochemistry."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        }
    ],
    "enzyme": {
        "name": "AoL4",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1039/d3sc04172g"
        ],
        "databaseIds": {
            "uniprot": "Q2U1B3",
            "genpept": "BAE64652.1"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "AoL4 is a P450 responsible for converting aristolochene to 8-hydroxy aristolochene",
            "reactionSMARTS": "[#6:1]1-[#6:15]-[#6@:13](\\[#6:14])-[#6@@:4]2(\\[#6:12])-[#6:5]-[#6@@:6](/[#6:9](-[#6:11])=[#6:10])-[#6:7]-[#6:8]=[#6:3]-2-[#6:2]-1>>[#6:1]1-[#6:15]-[#6@:13](\\[#6:14])-[#6@@:4]2(\\[#6:12])-[#6:5]-[#6@@:6](/[#6:9](=[#6:10])-[#6:11])-[#6@:7](\\[#8])-[#6:8]=[#6:3]-2-[#6:2]-1",
            "reactions": [
                {
                    "substrate": "C=C(C)[C@H]1CC=C2CCC[C@H](C)[C@@]2(C)C1",
                    "products": [
                        "C=C(C)[C@@H]1C[C@@]2(C)C(=C[C@H]1O)CCC[C@@H]2C"
                    ],
                    "isIntermediate": true,
                    "description": "Hydroxylation"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Inference from genomic data and chemical structure"
                ],
                "references": [
                    "doi:10.1039/d3sc04172g"
                ]
            }
        }
    ]
}