{
    "accession": "MITE0000199",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2025-05-10",
            "contributors": [
                "0000-0002-3823-1416"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "New entry. Reviewer 1 added more specific description to example"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        }
    ],
    "enzyme": {
        "name": "NodM",
        "description": "FAD-dependent monooxygenase",
        "references": [
            "doi:10.1021/jacs.7b10909"
        ],
        "databaseIds": {
            "uniprot": "A0A2I6PIZ2",
            "genpept": "AUM60051.1",
            "mibig": "BGC0001706"
        },
        "cofactors": {
            "organic": [
                "FAD"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Oxidation"
            ],
            "description": "Single epoxidation",
            "reactionSMARTS": "[#6:1](-[#6:2]-[#6:3]-[#6:4](=[#6:13]-[#6:12]1:[#6:16]2:[#6:17]:[#6:18]:[#6:19]:[#6:20]:[#6:15]:2:[#7:14]:[#6:11]:1)-[#6:5])=[#6:6](-[#6:28])-[#6:7]-[#6:8]-[#6:9]=[#6:10](-[#6:27])-[#6:21]-[#6:22]-[#6:23]=[#6:24](-[#6:26])-[#6:25]>>[#6:1](-[#6:2]-[#6:3]-[#6:4](=[#6:13]-[#6:12]1:[#6:16]2:[#6:17]:[#6:18]:[#6:19]:[#6:20]:[#6:15]:2:[#7:14]:[#6:11]:1)-[#6:5])=[#6:6](-[#6:28])-[#6:7]-[#6:8]-[#6:9]1-[#8]-[#6:10]-1(-[#6:27])-[#6:21]-[#6:22]-[#6:23]=[#6:24](-[#6:26])-[#6:25]",
            "reactions": [
                {
                    "substrate": "CC(C)=CCCC(C)=CCC/C(C)=C/CC/C(C)=C/c1c[nH]c2ccccc12",
                    "products": [
                        "CC(C)=CCCC1(C)OC1CCC(C)=CCCC(C)=Cc1c[nH]c2ccccc12"
                    ],
                    "isIntermediate": true,
                    "description": "Epoxidation of 3-geranylgeranylindole substrate in nodulisporic acid pathway."
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1021/jacs.7b10909"
                ]
            }
        }
    ]
}