{
    "accession": "MITE0000196",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-12-04",
            "contributors": [
                "0000-0001-6660-2715"
            ],
            "reviewers": [
                "0000-0001-7044-2419"
            ],
            "comment": "New entry"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "HynE",
        "description": "Alpha-ketoglutarate-dependent dioxygenase ",
        "references": [
            "doi:10.1002/anie.202102224"
        ],
        "databaseIds": {
            "genpept": "QWP75301.1",
            "mibig": "BGC0002126"
        },
        "auxiliaryEnzymes": [
            {
                "name": "HynA",
                "description": "nonribosomal peptide synthetase",
                "databaseIds": {
                    "genpept": "QWP75305.1"
                }
            }
        ],
        "cofactors": {
            "organic": [
                "a-Ketoglutaric acid"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Hydroxylation"
            ],
            "description": "beta-hydroxylation of PCP-bound asparagine (anti)",
            "reactionSMARTS": "[#6:1]-[#6:2](-[#6:10](-[#8:22])-[#6:11](-[#7:13]-[#6:14]-[#6:15]-[#6:16](-[#7:18]-[#6:19]-[#6:20]-[#16:21]-[#6:23](=[#8:26])-[#6@:24](/[#7:27])-[#6:25]-[#6:28](=[#8:30])-[#7:29])-[#8:17])-[#8:12])(-[#6:4]-[#8:5]-[#15:6](-[#8:9])(-[#8:8])-[#8:7])-[#6:3]>>[#6:3]-[#6:2](-[#6:10](-[#8:22])-[#6:11](-[#7:13]-[#6:14]-[#6:15]-[#6:16](-[#7:18]-[#6:19]-[#6:20]-[#16:21]-[#6:23](=[#8:26])-[#6@:24](/[#7:27])-[#6@:25](\\[#8])-[#6:28](=[#8:30])-[#7:29])-[#8:17])-[#8:12])(-[#6:4]-[#8:5]-[#15:6](-[#8:8])(-[#8:7])-[#8:9])-[#6:1]",
            "reactions": [
                {
                    "substrate": "CC(C)(CO[PH](O)(O)O)C(O)C(O)NCCC(O)NCCSC(=O)[C@H](N)CC(N)=O",
                    "products": [
                        "CC(C)(CO[PH](O)(O)O)C(O)C(O)NCCC(O)NCCSC(=O)[C@H](N)[C@H](O)C(N)=O"
                    ],
                    "isIntermediate": true,
                    "description": "beta-hydroxylation of PCP-bound asparagine (anti)"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1002/anie.202102224"
                ]
            }
        }
    ]
}