{
    "accession": "MITE0000194",
    "status": "active",
    "comment": "Previously associated with retired MIBIG ID BGC0003093",
    "changelog": [
        {
            "version": "1",
            "date": "2024-12-07",
            "contributors": [
                "0000-0001-6534-6609"
            ],
            "reviewers": [
                "0000-0001-7044-2419"
            ],
            "comment": "Initial entry. Check for factual correctness; link to UniParc (the UniProt Archive) as entry was retired in UniProtKB;"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "2",
            "date": "2026-07-03",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Removed retired MIBIG ID."
        }
    ],
    "enzyme": {
        "name": "PhoO",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1021/acs.orglett.2c01050"
        ],
        "databaseIds": {
            "uniprot": "UPI0020472753",
            "genpept": "UPG58744.1"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Biaryl bond formation"
            ],
            "description": "PhoO dimerizes penexanthone B to phomoxanthone A",
            "reactionSMARTS": "[#6:1]-[#6:2](-[#8:4]-[#6:5]\\[#6@@:6]12-[#6@:23](/[#8:24]-[#6:25](=[#8:27])-[#6:26])-[#6@:21](/[#6:22])-[#6:20]-[#6:18](-[#8:19])=[#6:17]-1-[#6:15](=[#8:16])-[#6:14]1:[#6:8](:[#6:9]:[#6:10]:[#6:11]:[#6:12]:1-[#8:13])-[#8:7]-2)=[#8:3]>>[#6:1]-[#6:2](-[#8:4]-[#6:5]\\[#6@@:6]12-[#6@:23](/[#8:24]-[#6:25](=[#8:27])-[#6:26])-[#6@:21](/[#6:22])-[#6:20]-[#6:18](-[#8:19])=[#6:17]-1-[#6:15](=[#8:16])-[#6:14]1:[#6:8](:[#6:9](-[#6]3:[#6]:[#6]:[#6](:[#6]4-[#6](-[#6]5=[#6](-[#6]-[#6@](-[#6@@](/[#8]-[#6](=[#8])-[#6])-[#6@]-5(-[#8]-[#6]:3:4)\\[#6]-[#8]-[#6](=[#8])-[#6])/[#6])-[#8])=[#8])-[#8]):[#6:10]:[#6:11]:[#6:12]:1-[#8:13])-[#8:7]-2)=[#8:3]",
            "reactions": [
                {
                    "substrate": "CC(=O)OC[C@]12Oc3cccc(O)c3C(=O)C1=C(O)C[C@@H](C)[C@H]2OC(C)=O",
                    "products": [
                        "CC(=O)OC[C@]12Oc3c(-c4ccc(O)c5c4O[C@@]4(COC(C)=O)C(=C(O)C[C@@H](C)[C@H]4OC(C)=O)C5=O)ccc(O)c3C(=O)C1=C(O)C[C@@H](C)[C@H]2OC(C)=O"
                    ],
                    "isIntermediate": false,
                    "description": "Dimerization of penexanthone B to phomoxanthone A via biaryl bond formation"
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression",
                    "In vitro assay"
                ],
                "references": [
                    "doi:10.1021/acs.orglett.2c01050"
                ]
            }
        }
    ]
}